USA flag logo/image

An Official Website of the United States Government

Asthma Treatment with a Novel Drug Aerosol Generator

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
70977
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
HL076953
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Alexza Molecular Delivery Corporation
Alexza Molecular Delivery Corporation 1001 E Meadow Cir Palo Alto, CA 94303
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Asthma Treatment with a Novel Drug Aerosol Generator
Agency: HHS
Contract: 1R43HL076953-01
Award Amount: $201,033.00
 

Abstract:

DESCRIPTION (provided by applicant): Asthma is a chronic disease characterized by inflammation of the airways and lung, causing attacks characterized by wheezing and shortness of breath. Around 5% of the population in the United States suffers from asthma, with the prevalence of this disease continuing to rise. The most common method to deliver asthma medications to patients is metered dose inhalers (MDIs). Traditional MDIs using chlorofluorocarbons (CFCs) will soon be phased out due to CFCs' ozone-depleting effect; a new class of propellants is being developed to replace CFCs. However, MDIs in general are not optimal for asthma treatment because of (1) the difficulty in coordinating actuation and inspiration, (2) excessively large particle size of generated aerosols inadequate for delivery to therapeutically important small bronchioles, and (3) difficulty in formulation. Other inhalation delivery platforms, such as dry powder inhalers and nebulizers, also have significant disadvantages in treating asthma; they include dose form instability, inconsistent emitted dose, and suboptimal aerosol particle size. All current inhalation delivery systems contain significant amounts of excipients; excipients in pulmonary delivery may induce airway hypersensitivity. Thus, there is a substantial need for an environmentally friendly alternative to current delivery systems that is able to generate aerosol particles with sizes suitable for drug delivery to small bronchioles and without excipients in the formulation. Alexza MDC has developed a novel technology to generate drug aerosol of high purity. The envisioned inhalation device for asthma drug delivery will be breath actuated and aerosols with appropriate particle sizes for delivery to small airways free of excipients. The goal in Phase I of the grant is to demonstrate the feasibility of building such a device that delivers albuterol, a common bronchodilator, with high purity and appropriate particle size for asthma treatment using this technology. Successful completion of activities in Phase I would present a significant step towards developing an improved inhalation drug delivery platform for asthma treatment.

Principal Investigator:

William W. Shen
6506873911
WSHEN@ALEXZA.COM

Business Contact:

Carol Christopher
6506873902
CCHRISTOPHER@ALEXZA.COM
Small Business Information at Submission:

ALEXZA MOLECULAR DELIVERY CORPORATION
ALEXZA MOLECULAR DELIVERY CORPORATION 1001 E MEADOW CIR PALO ALTO, CA 94303

EIN/Tax ID: 770567768
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No