Award Year / Program / Phase:2001 / SBIR / Phase I
Agency:HHS
Principal Investigator:Leonard P. Ruiz
Award Amount:$100,000.00
Abstract:
APPLICANT?S DESCRIPTION: Gene therapy will allow for the treatment of both
acquired and genetic diseases at the most fundamental level by introduction of
therapeutic genes. Despite advances in delivery of foreign genes, achieving
high and stable levels of expression has been problematic. The use of… More
Description (provided by applicant): The liver is the most important organ in metabolizing xenobiotics and drugs. Liver cells (hepatocytes) are used frequently in testing drug metabolism and hepatotoxicity. Hepatocytes in culture can form spheroids that exhibit higher liver-specific functions and… More