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A HEPATOCYTE SPHEROID BIOASSAY SYSTEM FOR DRUG DISCOVERY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60838
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
DK059109
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ALGENIX, INC.
ALGENIX, INC. 5264 OXFORD ST N SHOREVIEW, MN 55126
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: A HEPATOCYTE SPHEROID BIOASSAY SYSTEM FOR DRUG DISCOVERY
Agency: HHS
Contract: 1R43DK059109-01A2
Award Amount: $100,000.00
 

Abstract:

Description (provided by applicant): The liver is the most important organ in metabolizing xenobiotics and drugs. Liver cells (hepatocytes) are used frequently in testing drug metabolism and hepatotoxicity. Hepatocytes in culture can form spheroids that exhibit higher liver-specific functions and sustain high viability longer in culture. This proposed research is to develop an integrated system employing hepatocyte spheroids for both screening purposes and for metabolic studies. In phase I studies, we will develop a high throughput screening system suitable for integration with a miniaturized bioartificial liver for such studies. We will also demonstrate genetic metabolic engineering of hepatocyte spheroids. The analysis of the results will be facilitated by the use of a cDNA microarray immobilized with most relevant DNA sequences. The proposed work will fill a critical need for bioassay systems for high throughput screening.

Principal Investigator:

Leonard P. Ruiz
6514900212
LPRUIZ@ATTBI.NET

Business Contact:

Leonard Ruiz
6514900212
LPRUIZ@MN.MEDIAONE.NET
Small Business Information at Submission:

ALGENIX, INC.
ALGENIX, INC. 5264 OXFORD ST N SHOREVIEW, MN 55126

EIN/Tax ID: 954645312
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No