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TEC INHIBITORS- A NEW THERAPEUTIC FOR ALLERGIC DISEASES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60504
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
AI051125
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ALLIMMUNE, LLC
ALLIMMUNE, LLC 10355 SCIENCE CENTER DR SAN DIEGO, CA 92121
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: TEC INHIBITORS- A NEW THERAPEUTIC FOR ALLERGIC DISEASES
Agency: HHS
Contract: 1R43AI051125-01
Award Amount: $443,366.00
 

Abstract:

DESCRIPTION (provided by applicant): The incidence of allergic diseases such as atopic dermatitis (AD) has been dramatically increasing in the US and other industrialized countries for the past two decades. We and others have demonstrated that Tec family protein-tyrosine kinases have crucial roles in the activation of immune cells elicited by the engagement of antigen receptors or Fc receptors. As such, these kinases are supposed to play critical roles in the pathogenesis of AD and other allergic diseases that involve the activation of T and B lymphocytes, mast cells, and eosinophils. We recently identified a small-molecule compound, terreic acid (TA), as a selective inhibitor of Tec family kinases. In addition, we recently established highly efficient experimental conditions to rapidly induce skin lesions in AD-prone NC/Nga mice. Using this mouse model, we propose to explore whether TA or related compounds are therapeutically efficacious as a treatment of AD. Since we have a screening method for searching for Tec inhibitors whose usefulness has been proven, we will also expand our search for better compounds.

Principal Investigator:

Yuko Kawakami
8586784634
YUKO_KAWAKAMI@LIAI.ORG

Business Contact:

Charles Carpowich
8585583500
SKIP_CARPOWICH@LIAI.ORG
Small Business Information at Submission:

ALLIMMUNE, LLC
ALLIMMUNE, LLC 10355 SCIENCE CENTER DR SAN DIEGO, CA 92121

EIN/Tax ID: 330841007
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No