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SBIR Phase I: Chemoenzymatic Production of Innovative Sesquiterpene-Based…

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
88347
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
0741010
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Allylix Inc.
UK Coldstream Research Campus 1500 Bull Lea Road, Suite 205 Lexington, KY 40511 1267
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: SBIR Phase I: Chemoenzymatic Production of Innovative Sesquiterpene-Based Fragrance Libraries
Agency: NSF
Contract: 0741010
Award Amount: $100,000.00
 

Abstract:

This Small Business Innovation Research (SBIR) Phase I research project aims to develop a yeast-based platform for the generation of novel sesquiterpene compounds, as well as commercially unavailable sesquiterpene scaffolds. The technique combines metabolic, protein and biochemical approaches to produce defined sesquiterpene scaffolds, which are in turn, used to produce libraries of interesting compounds using combinatorial chemistry. The generated compounds are commercially valuable to the fragrance industry, but could also be screened for medically relevant properties. The mevalonate and non-mevalonate pathways are currently the only ones known to be used for the synthesis of isopentenyl pyrophosphate, one of the precursors to isoprenoids (terpenes), the most structurally diverse class of biological compounds. These precursors are converted to the terpenes through a series of enzymatic reactions. The proposed technology aims to leverage the understanding of the biochemistry and enzymology of the terpenes to develop a process that enables the production of thousands of new sesqueterpenes with interesting properties and great commercial value.

Principal Investigator:

Richard P. Burlingame
PhD
8592435776
rburlingame@allylix.com

Business Contact:

Richard P. Burlingame
PhD
8592435776
rburlingame@allylix.com
Small Business Information at Submission:

Allylix Inc.
UK Coldstream Research Campus 1500 Bull Lea Road, Suite 205 Lexington, KY 40511

EIN/Tax ID: 202718255
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No