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Company Information:

Company Name: Alpha Universe LLC
City: Madison
State: WI
Zip+4: 53713-2410
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $2,156,287.00 9
SBIR Phase II $499,996.00 1

Award List:

Tools for Targeted Delivery of DNA into Mammalian Cells

Award Year / Program / Phase: 2004 / SBIR / Phase I
Agency: HHS
Principal Investigator: Alexey G. Zdanovsky
Award Amount: $144,888.00
Abstract:
DESCRIPTION (provided by applicant): Viral vectors are the most efficient tools currently available for genetic modification of mammalian cells in vitro and in vivo. However, because protocols for the incorporation of DNA of interest into viral particles are rather lengthy and cumbersome, these… More

Suspension arrays detection/quantification of antibodies

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Alexey G. Zdanovsky
Award Amount: $160,243.00
Abstract:
DESCRIPTION (provided by applicant): In modern medicine and science there is a growing need for the ability to profile composition of such bodily fluids as serum and saliva. Microarray chip technology has potential for delivering such ability. This technology has already changed pharmaceutical… More

Approach for amplification of molecular signals

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Alexey G. Zdanovsky
Award Amount: $164,721.00
Abstract:
DESCRIPTION (provided by applicant): Antibody-based detection systems have been used for years in clinical diagnostics and environmental monitoring for the detection and identification of pathogenic agents. Recent advances in the field of low-level antigen detection utilize the DNA… More

Development of novel proteins as a defence against potential biothreat agents

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Alexey G. Zdanovsky
Award Amount: $538,625.00
Abstract:
DESCRIPTION (provided by applicant): The ongoing war on terror has created the necessity of a whole new spectrum of systems that are able to detect and inactivate biothreat agents, systems that are inexpensive to produce, robust and stable to allow their use on a massive scale by first responders or… More

Probes and cell arrays for detection of bacterial toxins

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Alexey G. Zdanovsky
Award Amount: $196,552.00
Abstract:
Microarray technology offers an opportunity for simultaneous monitoring of the behavior of multiple markers within a mammalian cell and ultimately could be used for detection and elucidation of mechanisms of action of different biologically active agents, including those that are considered a threat… More

Novel Approach for Fast and Economic Manufacturing of Human Antibodies

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $501,334.00
Abstract:
DESCRIPTION (provided by applicant): A growing number of potential native and engineered biothreat agents effectively limit the proactive protection of public health through vaccination. An alternative approach relies on the use of corresponding protective antibodies that are pre-made and are used… More

SBIR Phase I:Novel System for Targeting Nanobodies

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: NSF
Principal Investigator: Alexey G. Zdanovsky, PhD
Award Amount: $149,997.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project has the goal of creating a system that, while being inexpensive and simple to use, will be able to generate variable domains of heavy chain-only llama antibodies (also called VHHs, or nanobodies) targeted to antigens of interest in… More

SBIR Phase I:Phage detectors for bacterial pathogens

Award Year / Program / Phase: 2010 / SBIR / Phase I
Agency: NSF
Principal Investigator: Alexey G. Zdanovsky, PhD
Award Amount: $149,974.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project has a goal of creating a system that, while being inexpensive and simple to use, will be able to analyze samples for the presence of a live pathogenic bacteria and determine their species, as well as sensitivities to antibiotics within… More

SBIR Phase I: Inexpensive and effecient system for signal amplification

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: NSF
Principal Investigator: Alexey G. Zdanovsky
Award Amount: $149,953.00
Abstract:
This Small Business Innovation Research (SBIR) Phase I project has the goal of creating a signal amplification system that, while being inexpensive and simple to use, can be combined with antibodies or other probe molecules, and can increase detection limits of conventional ELISAs by 100- to… More

SBIR Phase II: Inexpensive and Effecient System for Signal Amplification

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: NSF
Principal Investigator: Alexey G. Zdanovsky
Award Amount: $499,996.00
Abstract:
This Small Business Innovation Research (SBIR) Phase II project proposes to develop a new signal amplification system that, while being inexpensive and simple to use, can be combined with antibodies or other probe molecules and can increase detection limits of conventional Enzyme-linked… More