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Empirical Statistical Estimation of Glucose Concentration Using Thermal…

Award Information

Agency:
Department of Defense
Branch:
Office of the Secretary of Defense
Award ID:
71912
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
O041-DH2-3039
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ALPHATECH, INC.
6 New England Executive Park Burlington, MA 01803
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Empirical Statistical Estimation of Glucose Concentration Using Thermal Radiation
Agency / Branch: DOD / OSD
Contract: W81XWH-04-C-0115
Award Amount: $99,996.00
 

Abstract:

OptiScan Biomedical Corporation's Non-Invasive Glucose Monitor has demonstrated the capability to measure patient blood glucose concentrations using an induced cyclic temperature variation that modulates the natural mid-infrared radiation coming from the patient's tissue just below the surface of the skin. ALPHATECH, Incorporated, can leverage the information extracted by this method using additional signal processing and nonlinear statistical modeling techniques. Glucose concentration affects IR absorption and hence the detected amplitude and phase at the thermal driving frequency. Currently, only the phase information is exploited in the Glucose Monitor. Modeling the signal amplitude and phase within a Support Vector Machine (SVM) framework, an initial simulation shows that the SVM predictive error is a factor of five smaller than that of a linear model. Both the linear and SVM model methods account for confounding variables in the simulation, and offer the potential for estimating the concentrations of other analytes of interest for metabolic monitoring and disease diagnosis. The ALPHATECH-OptiScan team proposes to demonstrate that advanced nonlinear methods are capable of accurately estimating glucose concentration levels in the presence of confounding metabolites in in vitro tests as the first step in the development of a breakthrough noninvasive metabolic monitoring device.

Principal Investigator:

Gary Jahns
Principal Engineer
8588123173
Gjahns@alphatech.com

Business Contact:

John J. Barry
Contracts Manager
7812733388
jbarry@alphatech.com
Small Business Information at Submission:

ALPHATECH, INC.
6 New England Executive Park Burlington, MA 01803

EIN/Tax ID: 042654515
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No