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T-cell receptor based therapeutics for cytomegalovirus

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65951
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
AI056782
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
X
2810 N COMMERCE PKY MIRAMAR, FL -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: T-cell receptor based therapeutics for cytomegalovirus
Agency: HHS
Contract: 1R43AI056782-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by investigator): The goal of these studies is to evaluate the feasibility of using a T-cell receptor based fusion protein as a targeting agent for therapies for CMV, which remains a major cause of morbidity and mortality inimmunocompromised patients. For these studies a TCR recognizing a distinct, naturally processed, highly immunogenic peptide fragment from the human cytomegalovirus tegument protein pp65 presented on the cell surface in the context of HLA-A2 was cloned. This TCR was isolated from CMV peptide specific CD8+ T-cells that were generated by CMV peptide stimulation of HLA-A2 positive human PBMC. A CMV specific single chain TCR/IgG1 fusion protein, CMVscTCR/IgG1, was prepared and will be expressed at high levels in mammalian cells and purified for characterization. The fusion protein will be characterized in vitro for MHC restricted peptide specific binding, stability, affinity, ability to target antigen positive cells, and ability to conjugate target and effector cells. Finally, the CMVscTCR/IgG1 fusion protein will be evaluated in vivo for pharmacokinetics and toxicity. Successful completion of these studies will lead to in vivo efficacy studies in a novel mouse model of human CMV infection and to eventual production of TCR-based targeted CMV therapeutics for commercialization.

Principal Investigator:

Hing C. Wong
9544438600
HINGWONG@ALTORBIOSCIENCE. COM

Business Contact:


9544438600
Small Business Information at Submission:

ALTOR BIOSCIENCE CORPORATION
ALTOR BIOSCIENCE CORPORATION 2810 N COMMERCE PKY MIRAMAR, FL 33025

EIN/Tax ID: 050523659
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No