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NOVEL DRUG DISCOVERY FOR MULTIPLE SCLEROSIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66688
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
NS047767
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
X
2810 N COMMERCE PKY MIRAMAR, FL -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: NOVEL DRUG DISCOVERY FOR MULTIPLE SCLEROSIS
Agency: HHS
Contract: 1R43NS047767-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): The long-term objective of this project is to develop small molecule inhibitors of TCR:MHC class II-peptide interactions for the treatment of multiple sclerosis (MS). The strong genetic association between specific MHC class ll alleles, such as HLA-DR2 (DRB1*1501), and susceptibility to MS provides support to a mechanism in which disease-associated MHC molecules selectively present myelin antigens that activate CD4 T cells. The hypothesis of this project is that small molecules that block TCR:HLA-DR2/peptide complex formation can prevent autoreactive T cell activation and chronic inflammatory processes in MS lesions. The investigator has developed sensitive screening assays to detect TCR:HLA-DR2/peptide interactions and methods to produce sufficient amounts of soluble and functional TCR and HLA-DR2/peptide reagents to support analysis of librarys of small molecules. Preliminary studies with another TCR:pMHC pair demonstrate that compounds that inhibit TCR:pMHC interaction can be identified using these screening methods. The specific aims of the project are to further develop high-throughput screening assays to identify and characterize small molecules that inhibit TCR:HLA-DR2/peptide interactions, to examine a large and diverse collection of small molecules for inhibitory activity and to test the immunosuppressive effects of these compounds in T cell-based assays. The results from these studies will provide useful information about TCR:pMHC interactions and could form the basis of a novel class of immunosuppressive drugs to treat human T-cell mediated autoimmune diseases.

Principal Investigator:

Peter R. Rhode
9544438600
PETERRHODE@ALTORBIOSCIENCE.COM

Business Contact:


9544438600
Small Business Information at Submission:

ALTOR BIOSCIENCE CORPORATION
ALTOR BIOSCIENCE CORPORATION 2810 N COMMERCE PKY MIRAMAR, FL 33025

EIN/Tax ID: 050523659
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No