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NOVEL DRUG DISCOVERY FOR MULTIPLE SCLEROSIS
- Small Business Information
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Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
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Fiscal Year: 2003Title: NOVEL DRUG DISCOVERY FOR MULTIPLE SCLEROSISAgency: HHSContract: 1R43NS047767-01Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): The long-term objective of this project is to develop small molecule inhibitors of TCR:MHC class II-peptide interactions for the treatment of multiple sclerosis (MS). The strong genetic association between specific MHC class ll alleles, such as HLA-DR2 (DRB1*1501), and susceptibility to MS provides support to a mechanism in which disease-associated MHC molecules selectively present myelin antigens that activate CD4 T cells. The hypothesis of this project is that small molecules that block TCR:HLA-DR2/peptide complex formation can prevent autoreactive T cell activation and chronic inflammatory processes in MS lesions. The investigator has developed sensitive screening assays to detect TCR:HLA-DR2/peptide interactions and methods to produce sufficient amounts of soluble and functional TCR and HLA-DR2/peptide reagents to support analysis of librarys of small molecules. Preliminary studies with another TCR:pMHC pair demonstrate that compounds that inhibit TCR:pMHC interaction can be identified using these screening methods. The specific aims of the project are to further develop high-throughput screening assays to identify and characterize small molecules that inhibit TCR:HLA-DR2/peptide interactions, to examine a large and diverse collection of small molecules for inhibitory activity and to test the immunosuppressive effects of these compounds in T cell-based assays. The results from these studies will provide useful information about TCR:pMHC interactions and could form the basis of a novel class of immunosuppressive drugs to treat human T-cell mediated autoimmune diseases.Small Business Information at Submission:Business Contact:
9544438600ALTOR BIOSCIENCE CORPORATION
ALTOR BIOSCIENCE CORPORATION 2810 N COMMERCE PKY MIRAMAR, FL 33025EIN/Tax ID: 050523659DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
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Agency: Department of Health and Human Services |
Branch: N/A |
Award ID: 66688 |
Program Year/Program: 2003 / SBIR |
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Agency Tracking Number: NS047767 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |