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PROTEOME ARRAY FOR GLOBAL MAPPING OF CELLULAR PATHWAYS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60540
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
AI052525
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AMBERGEN, INC
AMBERGEN, INC 313 PLEASANT ST WATERTOWN, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: PROTEOME ARRAY FOR GLOBAL MAPPING OF CELLULAR PATHWAYS
Agency: HHS
Contract: 1R43AI052525-01
Award Amount: $599,682.00
 

Abstract:

DESCRIPTION (provided by applicant): Based on recent progress in sequencing the human genome, a new goal has emerged: to express and analyze the human proteome. The development of proteome arrays will accelerate progress in several key areas of biology and medicine including mapping cellular pathways, discovering new drug targets and identifying disease related biomarkers. However, the production of proteome arrays is currently hindered by the need for improved methods of expressing proteins from gene libraries, engineering proteins for site-specific surface attachment and detecting multiple protein-protein interactions. This project aims to overcome these limitations by combining cell-free methods for rapid expression of specially engineered protein libraries with advanced technology for microarray fabrication and readout.AmberGen will produce and evaluate proteome arrays constructed from cell-free expressed protein libraries and designed for high sensitivity and multiplex readout. The rapid detection of protein-protein interactions will be used to map cellular pathways and to discover new biomarkers. Prototype proteome arrays from the pathogen H. pylori and selected genes from the human genome will be constructed and evaluated in Phase I. Phase II will focus on applications in the areas of autoimmune and infectious diseases.

Principal Investigator:

Jerzy Olejnik
6179750685
JERZY@AMBERGEN.COM

Business Contact:

Norman Priebatsch
6179750688
NEP@AMBERGEN.COM
Small Business Information at Submission:

AMBERGEN, INC.
AMBERGEN, INC. 1106 COMMONWEALTH AVE BOSTON, MA 02215

EIN/Tax ID: 043228005
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No