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MicroRNA Expression Profiling

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
70858
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
HG003430
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AMBION DIAGNOSTICS, INC.
Asuragen, Inc. 2150 WOODWARD ST AUSTIN, TX -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: MicroRNA Expression Profiling
Agency: HHS
Contract: 1R43HG003430-01
Award Amount: $203,747.00
 

Abstract:

DESCRIPTION (provided by applicant): MicroRNAs are small, 19-25mer RNAs that are encoded in the genomes of upper eukaryotes. MicroRNAs appear to regulate global gene expression by modulating the translation of mRNAs transcribed from key genes. Although the research field is still young, microRNAs have been implicated in early development, brain development, cell differentiation, apoptosis, and tumor progression. Like mRNA analysis, defining miRNA expression profiles in samples should make it possible to identify miRNAs that are involved in a wide variety of bioogical processes. Towards this end, we propose to create methods for miRNA isolation, labeling, and microarray analysis that will make it possible to catalogue the miRNA profiles of any sample. The procedures will incorporate labeling and array procedures that will allow existing microarray instruments to be used for miRNA analysis.

Principal Investigator:

David M. Brown
5126510200
DBROWN@AMBION.COM

Business Contact:

Rigo Vallejo
5126510200
RVALLEJO@AMBION.COM
Small Business Information at Submission:

AMBION, INC.
2130 WOODWARD STREET AUSTIN, TX 78744

EIN/Tax ID: 742515119
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No