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Aging Resistant Ceramics for Total Hip Arthroplasty

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
66169
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
HD044370
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Amedica Corporation
615 Arapeen Drive, Suite 302 Salt Lake City, UT 84108
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Aging Resistant Ceramics for Total Hip Arthroplasty
Agency: HHS
Contract: 1R43HD044370-01
Award Amount: $99,379.00
 

Abstract:

DESCRIPTION (provided by applicant): Zirconia bio-ceramics (e.g. Prozyr) have the highest toughness and strength compared to other bio-ceramics such as alumina (e.g. Biolox) or zirconia-toughened alumina (Biolox-Delta). However, as highlighted by the recent recall of St. Gobain zirconia heads, a critical need remains to develop bio-ceramics with both significantly reduced wear characteristics and reduced fracture risk in-vivo. Theoretical calculations and practical demonstration show that damage resistance in many ceramic systems has been significantly improved by imparting insurface compression. This mechanism will be employed by providing a layered composite structure to make ceramics with significantly enhanced wear resistance. A novel doping strategy will be used to improve aging resistance of zirconia. By these enhancements the investigators propose to demonstrate feasibility and merits of advanced zirconia toughened alumina (ZTA) composites as a replacement for CoCr femoral heads and currently used alumina and zirconia femoral heads. This should lead to a simultaneous dramatic reduction in wear and catastrophic failure risk, thereby addressing and eliminating one of the most important clinical problems in total-hip arthroplasty (THA). In this phase I project, the aging resistance of the zirconia will be improved by adding suitable dopants to shift the martensitic start temperature far below in-vivo temperatures. Amount of monoclinic content in the matrix measured using XRD, after autoclaving will be the indicator of the aging resistance. The strength of this aging resistant zirconia is further improved by a suitable choice of the matrix. In addition by careful design of surface compression further improvement in strength and fracture toughness can be attained. The strength and fracture toughness will be measured using ASTM protocols C-1161 and E-399. Finally, wear performance will be evaluated using pin-on-disk wear tester and compared to the performance of currently available zirconia and alumina materials used for femoral heads. The three-step characterization will establish the superior performance of ACe-TZP materials over the currently existing alumina and zirconia materials for THA.

Principal Investigator:

R. Lakshminarayanan
8012482030
ALAN@AMEDICACORP.COM

Business Contact:


8012315729
Small Business Information at Submission:

AMEDICA CORPORATION
AMEDICA CORPORATION 2116 S LAKELINE DR SALT LAKE CITY, UT 84109

EIN/Tax ID: 841375299
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No