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GOOD RECOVERY OF MOTOR FUNCTION FOLLOWING SEVERE DAMAGE TO THE HUMAN NERVOUS…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3310
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3310
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
American Biointerface Corp
Box 1017 Cooper Station New York, NY 10276
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: GOOD RECOVERY OF MOTOR FUNCTION FOLLOWING SEVERE DAMAGE TO THE HUMAN NERVOUS SYSTEM, PRIMARILY THE CENTRAL NERVOUS SYSTEM, IS DIFFICULT TO ACHIEVE.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

GOOD RECOVERY OF MOTOR FUNCTION FOLLOWING SEVERE DAMAGE TO THE HUMAN NERVOUS SYSTEM, PRIMARILY THE CENTRAL NERVOUS SYSTEM, IS DIFFICULT TO ACHIEVE. THERE MAY BE A NUMBER OF REASONS WHY THE REGENERATIVE RESPONSE TO INJURY WOULD NOT LEAD TO FUNCTIONAL RECOVERY, AND A VARIETY OF METHODOLOGIES HAVE EMERGED TO MANIPULATE THE REGENERATIVE RESPONSE TO INJURY. SUCH METHODOLOGIES INCLUDE MUSCLE TRANSPLANTATION, WHICH IS IMPORTANT IN STUDYING THE REINNERVATION PROCESS, AND IN VITRO TECHNIQUES, UTILIZING A NUMBER OF ELECTROPHYSIOLOGICAL SYSTEMS. THIS PROPOSAL DEALS WITH TESTING THE ABILITY OF A DEVICE TO ATTRACT REGENERATING NEURITES FOR SYNAPTIC CONTACT IN AN IN VITRO PREPARATION. WE WILL ALSO DETERMINE WHETHER IT IS POSSIBLE TO RECORD THE ACTIVITY OF THE ELECTRICALLY EXCITABLE ELEMENTS UPON WHICH SYNAPTIC CONTACT IS MADE. IF THIS FUNCTION OF THE DEVICE CAN BE PARALLELED IN VIVO (SUCH AS IN THE SCIATIC NERVE), THEN IT MAY BE POSSIBLE TO UTILIZE THE ELECTRICAL ACTIVITY OF THE NERVOUS SYSTEM FOR SUBSEQUENT MODULATION OF ELECTRONIC DEVICES (I.E., FOR MUSCLE STIMULATION OR LIMB PROSTHETICS) TO ENABLE THE PARTIAL RESTORATION OF MOTOR CONTROL. IT MAY ALSO BE POSSIBLE TO USE SUCH A COMPATIBLE INTERFACING DEVICE IN PORTIONS OF THE DAMAGED CENTRAL NERVOUS SYSTEM.

Principal Investigator:

Michael f. zanakis
PRINCIPAL INVESTIGATOR
2124750732

Business Contact:

Small Business Information at Submission:

American Biointerface Corporat
P.o. Box 1017 Cooper Station New York, NY 10276

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No