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THE GOAL OF THIS PROJECT WILL BE TO SCREEN NEW DERIVATIVES OF L-ASCORBIC ACID…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3007
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3007
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
American Biotechnology Co
7658 Standish Pl - Ste 107 Rockville, MD 20855
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: THE GOAL OF THIS PROJECT WILL BE TO SCREEN NEW DERIVATIVES OF L-ASCORBIC ACID ADDUCTS CLASSIFIED AS METHYLFURYLBUTYROLACTONES, ALSO REFERRED TO AS NAFOCARE B.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE GOAL OF THIS PROJECT WILL BE TO SCREEN NEW DERIVATIVES OF L-ASCORBIC ACID ADDUCTS CLASSIFIED AS METHYLFURYLBUTYROLACTONES, ALSO REFERRED TO AS NAFOCARE B. WORKING IN COLLABORATION WITH A SYNTHETIC ORGANIC CHEMISTRY GROUP AT WEST VIRGINIA UNIVERSITY, WE HAVE DETERMINED THAT THE PARENT COMPOUND, MFBL, HAS EXTENSIVE IMMUNE POTENTIATING ACTIVITY. OUR PROJECT WILL ANALYZE FIVE NEW DERIVATIVES OF L-ASCORBIC ACID IN AN ATTEMPT TO VERIFY WHICH PROSTHETIC GROUPS OTHER THAN THE BUTYROLACTONE STRUCTURE ARE CRITICAL TO BIOLOGICAL ACTIVITY. IN ADDITION, WE HOPE TO DISCOVER NEW SYNTHETIC IMMUNE BIOLOGICAL RESPONSE MODIFIERS. ALL TEST COMPOUNDS WILL BE SCREENED PRESUMPTIVELY USING THE MOUSE LYMPHOCYTE STIMULATION ASSAY. IF THE COMPOUND IS POSITIVE FOR ACTIVITY, FURTHER CONFIRMATORY IMMUNOASSAYS WILL BE PERFORMED USING T-CELL, B-CELL, AND MACROPHAGE EFFECTOR CELLS.

Principal Investigator:

Robert w. veltri
PRINCIPAL INVESTIGATOR
3012949553

Business Contact:

Small Business Information at Submission:

American Biotechnology Co., In
7658 Standish Place, Suite 107 Rockville, MD 20855

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No