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ALTHOUGH INVESTIGATION INTO BIOLOGICAL RESPONSE MODIFIERS HAS INCREASED…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3008
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
3008
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
American Biotechnology Co
7658 Standish Pl - Ste 107 Rockville, MD 20855
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: ALTHOUGH INVESTIGATION INTO BIOLOGICAL RESPONSE MODIFIERS HAS INCREASED RECENTLY, MOST OF THE EFFORT HAS BEEN TOWARDS POTENTIATING THE HOST'S CELL-MEDIATED IMMUNITY.
Agency: HHS
Contract: N/A
Award Amount: $48,529.00
 

Abstract:

ALTHOUGH INVESTIGATION INTO BIOLOGICAL RESPONSE MODIFIERS HAS INCREASED RECENTLY, MOST OF THE EFFORT HAS BEEN TOWARDS POTENTIATING THE HOST'S CELL-MEDIATED IMMUNITY. DATA ACCUMULATED BY OUR LABORATORIES INDICATE THAT THE METHYLFURYLBUTYROLACTONE (MFBL) CLASS OF COMPOUNDS REPRESENTS NEW SYNTHETIC IMMUNE RESPONSE MODIFIERS CAPABLE OF ACTIVATING SEVERAL COMPONENTS OF IMMUNE RESPONSE WITH NEGLIGIBLE TOXICITY TO THE HOST. THIS PROPOSAL DESCRIBES RESEARCH DESIGNED TO ANALYZE ONE ASPECT OF THE IMMUNOSTIMULATORY ACTIVITY OF MFBLS, THE ABILITY TO STIMULATE ANTIBODY PRODUCTION. PHASE I RESEARCH WILL CONCENTRATE ON THE OPTIMIZATION OF TREATMENT REGIMENS AND THE EVALUATION OF THE RANGE OF ACTIVITY OF THE DRUGS TOWARD THE PRIMARY AND SECONDARY ANTIBODY RESPONSE TO T-DEPENDENT AND T-INDEPENDENT ANTIGENS. WE FURTHER INTEND TO STUDY THE EFFECT OF MFBL IN VIVO ON THE IMPROVEMENT OF THE QUALITY AND QUANTITY OF ANTIBODY PRODUCTION IN MICE AS THAT RELATES TO MONOCLONAL ANTIBODY TECHNOLOGY. IN ADDITION, WE WILL ASSESS MURINE IN VITRO ANTIGEN SENSITIZATION

Principal Investigator:

Peter e. maxim
PRINCIPAL INVESTIGATOR
3012949553

Business Contact:

Small Business Information at Submission:

American Biotechnology Co., In
7658 Standish Place, Suite 107 Rockville, MD 20855

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No