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INTERFACE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4784
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4784
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
American Biotechnology Co
7658 Standish Pl - Ste 107 Rockville, MD 20855
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: INTERFACE
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

A MAJOR OBJECTIVE OF THIS STUDY IS TO INVESTIGATE THE UTILITY OF A NEW AND INNOVATIVE LIQUID MICROCARRIER (MC) SYSTEM FOR CLONING AND PROPAGATING HUMAN TUMOR CELLS IN VITRO. THIS NEW PATENTED TECHNOLOGY IS AN OIL EMULSION OF DEFINED DROPLET SIZE (100 TO 200 MM) HAVING A SMOOTH, PLIABLE, AND TRANSPARENT SURFACE. THE PROTEIN AT THE OIL EMULSION INTERFACE CAN DIRECTLY SUPPORT THE GROWTH OF TRANSFORMED CELLS, OR THESE LAYERS CAN BE DESIGNED TO CONTAIN PROTEINS IMPORTANT TO THE ATTACHMENT AND SPREADING OF NORMAL OR MALIGNANTLY TRANSFORMED CELLS. ABC, LTD., WILLPREPARE MC OIL EMULSION MICROCARRIERS CONDUCTIVE TO THE ATTACHMENT AND GROWTH OF HUMAN TUMOR CELLS IN THIS PHASE I PROJECT. THE NEW MC SYSTEM WILL BE COMPARED TO THE CURRENT TWO-LAYER SOFT AGAR CLONING METHODOLOGY USING PRIMARY TISSUE SAMPLES OBTAINED FROM PATIENTS AT SURGERY. THE PROTOTYPE OIL EMULSION MC WILL BE OF VALUE TO CLONING AND PROPAGATING PRIMARY HUMAN TUMORS FOR USE IN CHEMOSENSITIVITYASSAYS. IN ADDITION, THIS TECHNOLOGY CAN PROVIDE A SOURCE OF TUMOR CELL ANTIGENS FOR PREPARING MONOCLONAL ANTIBODIES FOR TUMOR-SPECIFIC IMMUNOTHERAPY. PHASE II WILL INVOLVE THEAPPLICATION OF THE MC TECHNOLOGY TO THE THERAPEUTIC APPLICATIONS STATED IN THE AREAS OF CHEMOSENSITIVITY AND IMMUNOTHERAPY.

Principal Investigator:

Robert w veltri
PRINCIPAL INVESTIGATOR
3012949553

Business Contact:

Small Business Information at Submission:

American Biotechnology Co., In
7658 Standish Place Suite 107 Rockville, MD 20855

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No