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Nano-carbon Compounds as High Contrast Agents for MRI

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65390
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
CA101063
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AMERICAN HIGHTECH MATERIALS COMPANY
AMERICAN HIGHTECH MATERIALS COMPANY 2212 GLACIER DR DAVIS, CA 95616
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Nano-carbon Compounds as High Contrast Agents for MRI
Agency: HHS
Contract: 1R43CA101063-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): Magnetic resonance imaging (MRI) provides high-quality spatial resolution and does not use radiation. Contrast agents play a significant role in improving the quality of diagnostic imaging by increasing the contrast between the different internal structures or types of tissue in various disease stage and medical condition of interest. With the advent of Gadolinium-chelate complex for MR1 contrast agents, where the proton relaxation rate is enhanced by the presence of the paramagnetic Gd ions, great efforts are sought to develop new contrast materials with several orders of magnitude of higher resolutions than existing contrast media, such as Gd-DPTA. Endohedral metallofullerenes are promising candidates for new generation of MRI contrast materials. In this SBIR project, AHM is going to develop new water-soluble metallofullerenols for in vitro and in rive MRI studies. High yield production of metallofullerenes will lay foundation for new drug design and for developing techniques for diagnosis and treatment. For example, functional endohedral metallofullerene derivatives are designed and developed for specific cancer tissue targeting. Furthermore, by introducing one or two irradiated metal atom(s) into carbon cage, diagnosis and treatment may only require one injection, which results in a great reduction of health cost and to improve the quality of patients' life. SBIR funding will speed up this research project. The participation of the University of California at Davis is key to the success in exploring the new contrast agents.

Principal Investigator:

Jizhe Liu
5307586617
AHM_LIU@YAHOO.COM

Business Contact:


5307586617
Small Business Information at Submission:

AMERICAN HIGHTECH MATERIALS COMPANY
AMERICAN HIGHTECH MATERIALS COMPANY 2212 GLACIER DR DAVIS, CA 95616

EIN/Tax ID: 680354322
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No