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Hematological Diagnosis of Sickle Cell Anemia

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22313
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22313
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AMERICAN LABORATORY SUPPLIES
2000 N 14TH ST, STE 530 ARLINGTON, VA 22201
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Woman-Owned: Yes
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Hematological Diagnosis of Sickle Cell Anemia
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

Sickle cell anemia is an inherited disorder of erythrocytes characterized by chronic anemia, recurrent pain, susceptibility to infections, chronic and recurrent organ dysfunction, and diminished life-expectancy. Even among patients having documented homozygous sickle cell anemia (Hb SS), there exists an astonishing degree of variability in clinical severity. Some die from strokes as young children, others live well into their seventies. Some seek medical attention for pain weekly, others go years without pain. The absolute nature of current therapeutic measures for sickle cell disease (SCD), e. g. termination of pregnancy and bone marrow transplantation (BMT), emphasizes the importance of pretherapeutic predictions of mild and severe disease before the nature of the disease has been declared. In this regard, we propose to use polymerase chain reaction (PCR)-based methods to detect sequence variations that are related to disease severity - alpha-globin genotypes, beta-cluster restriction fragment length polymorphism (RFLP) haplotypes, binding sites for erythroid-specific trans-acting transcription elements, and beta-cluster locus control region (LCR) sequences. PCR-based methods for detecting these sequences will provide the basis for developing a diagnostic kit that will predict whether SCD will be mild or severe. PCR based methods will also guide decisions regarding termination of pregnancy and undertaking BMT.

Principal Investigator:

Gerald L. Kropp
7035583400

Business Contact:

Small Business Information at Submission:

C. P. Li Biomedical Research
2000 N. 14th Street Arlington, VA 22201

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No