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ELECTROSPRAY TIME-OF-FLIGHT MASS SPECTROMETRY WITH PRC

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
11273
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
11273
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANALYTICA OF BRANFORD, INC.
29 BUSINESS PARK DRIVE BRANFORD, CT 06405
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: ELECTROSPRAY TIME-OF-FLIGHT MASS SPECTROMETRY WITH PRC
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

AN ELECTROSPRAY (ES) ION SOURCE WILL BE INTERFACED TO A TIME-OF-FLIGHT (TOF) MASS SPECTROMETER INCORPORATING A PSEUDO-RANDOM-CHOPPING TECHNIQUE. THE TOF MASS SPECTROMETERWILL ALLOW RAPID SCAN RATES AND HIGH-MASS ANALYSIS FOR MULTIPLE AND SINGLY CHARGED IONS DELIVERED FROM THE ES ION SOURCE. USING A PSEUDO-RANDOM-CHOPPING APPROACH FOR OSCILLATING THE ES ION BEAM ACROSS AN ORIFICE INSTEAD OF THE STANDARD PERIODIC CHOPPING PATTERN CAN INCREASE THE DUTY CYCLE POTENTIALLY BY A FACTOR OF 10. THIS INCREASED DUTY CYCLE INCREASES SENSITIVITY PROPORTIONALLY WITHOUT SACRIFICING RESOLUTION. ASSEMBLY OF THE ES-TOF INSTRUMENT AND TESTING OF THE PSEUDO-RANDOM-CHOPPING TECHNIQUE WILL BE CONDUCTED IN PHASE I. THIS INSTRUMENT WILL ALLOW VERY HIGH-MASS ANALYSIS AND ON-LINE LIQUID FEED SYSTEM DETECTION WITH EXTREMELY GOOD SENSITIVITY. WITH ES AS THE INTERFACE, THIS ES-TOF INSTRUMENT CAN BE USED AS A LC/MS OR A CZE/MS ANALYZER. MORE SENSITIVE MS/MS APPLICATIONS COULD BE ACHIEVED WITH THIS ES-TOF INSTRUMENT IN PART DUE TO THE MULTIPLE CHARGING POSSIBLE IN ES.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Analytica Of Branford Inc
29 Business Park Dr Branford, CT 06405

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No