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Electrospray Ion Trap Time of Flight Mass Spectrometry

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
25195
Program Year/Program:
1996 / SBIR
Agency Tracking Number:
25195
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANALYTICA OF BRANFORD, INC.
29 BUSINESS PARK DRIVE BRANFORD, CT 06405
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1996
Title: Electrospray Ion Trap Time of Flight Mass Spectrometry
Agency: HHS
Contract: 1 R43 MH52510-1,
Award Amount: $532,175.00
 

Abstract:

A novel combination of techniques is proposed as a mass detector for biological compounds.A quadruple ion trap is used as a storage device for ions introduced from an Electrospray ionizationsource, thereby providing 100% duty cycle, while a reflection time-of-flight mass spectrometer is usedfor the rapid and highly sensitive mass analysis of ion bunches expelled from the ion trap on asub-second time frame. This instrument would be ideally suited as a high sensitivity detector for variousseparations systems. Its ability to effectively mediate samples between a continuous ion source and apulsed mass analyzer without requiring expensive detection electronics would be a performancebreakthrough, providing an important analytical method in a potentially inexpensive MS package. Sucha hybrid instrument would have the capability of providing highly accurate molecular weight andstructural information for a wide variety of biological compounds, while at the same time possessingsensitivity characteristics currently unattainable on either dispersive or even other time-of-flightplatforms. A low cost, modular approach will be used to demonstrate this technology on an existingElectrospray TOF instrument, optimizing sensitivity and mass resolution by using a gridless ion mirror.A minimal control strategy will be adopted to remove operational complexity and afford access tonon-MS Arts with a wide variety of analytical backgrounds.

Principal Investigator:

James Boyle
2034888899

Business Contact:

Small Business Information at Submission:

Analytica Of Branford, Inc.
29 Business Park Drive Branford, CT 06405

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No