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Vacuum Ultraviolet Ion Source for Small Biological Molecules

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22446
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22446
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANALYTICA OF BRANFORD, INC.
29 BUSINESS PARK DRIVE BRANFORD, CT 06405
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Vacuum Ultraviolet Ion Source for Small Biological Molecules
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

A laser-driven Vacuum Ultraviolet (VUV) photoionization source is proposed as a general purpose, high efficiency device for creating ionized species of biological molecules of several hundred amu or less in the gaseous phase. The high energy of the monochromatic VUV photons produced allows single photon ionization without resonant absorption considerations, while maintaining low power densities avoids multiphoton (and hence excessive fragmentation) events. As a direct result, loss of the parent specie is greatly reduced for a wide array of compounds, placing a substantial portion of the ion current in the molecular ion of interest. This feature may be especially advantageous if attempting to monitor mixtures of compounds or incompletely separated effluents from chromatography systems. The ability to couple this ionization scheme to an Electrospray Time-of- Flight Mass Spectrometer as a complementary technique will allow simultaneous, real-time detection of a wider range of species than is currently possible, including low molecular weight peptides, nucleic acid constituents, metabolites and pharmaceutical agent. The device is simple in both design and operation, is inherently a pulsed system which interfaces straight forwardly to TOF-MS instruments, and yields very high mass resolving powers due to its spatially focussed output. It could be incorporated into existing TOF mass spectrometers or built as a dedicated instrument.

Principal Investigator:

James G. Boyle
2034888899

Business Contact:

Small Business Information at Submission:

Analytica Of Branford, Inc.
29 Business Park Drive Branford, CT 06405

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No