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New Materials for Plague Antigen and Antibody Detection

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65907
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
AI052872
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANALYTICAL BIOLOGICAL SERVICES, INC.
ANALYTICAL BIOLOGICAL SERVICES 701-4 CORNELL BUSINESS PARK WILMINGTON, DE 19801
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: New Materials for Plague Antigen and Antibody Detection
Agency: HHS
Contract: 1R43AI052872-01A1
Award Amount: $98,530.00
 

Abstract:

DESCRIPTION (provided by applicant): We propose to develop novel soluble sensing materials that can be used in homogenous fluorescence assays for the detection of Yersinia pestis antigens and antibodies. Y. pestis is the etiological cause of plague and a potential biowarfare agent. The sensing materials are solutions of functionalized liposomes that become fluorescent when they bind selectively to the antibody targets. The solutions will be used to develop both competitive assays for detection of the Y. pestis F1 antigen and direct one-step assays for the detection of Y. pestis antibodies that can be performed in commonly available plate readers. Swift identification of a Y. pestis infection is very important to insure timely and appropriate treatment. Current methods of diagnosis (culture, fluorescent antibody staining, agglutination tests) are slow, complicated, require trained personnel and are not suitable for screening large numbers of samples quickly, in the advent of a biological attack. ELISA and PCR methods for detection of Y. pestis infection are in development, however, these methods also require multiple steps, expensive reagents and/or equipment. The assays developed from our sensing materials will be inexpensive, reliable, simple and swift. The materials will subsequently be adapted for detection of antibody response to other diseases, for medical diagnostics and vaccine research.

Principal Investigator:

Mary A. Reppy
3026544492
REPPY@ABSBIO.COM

Business Contact:

Charles Saller
3026544492
CSALLER@ABSBIO.COM
Small Business Information at Submission:

ANALYTICAL BIOLOGICAL SERVICES, INC.
ANALYTICAL BIOLOGICAL SERVICES 701-4 CORNELL BUSINESS PARK WILMINGTON, DE 19801

EIN/Tax ID: 510324951
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No