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HEMOFILTRATION CONTROL SYSTEM

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
2942 		Program Year/Program:
1986 / SBIR
Agency Tracking Number:
2942 		Solicitation Year:
N/A 		Solicitation Topic Code:
N/A 		Solicitation Number:
N/A
Small Business Information
Amnis Corporation
2505 Third Avenue, Suite 210 Seattle, WA 98121 0148
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1986
Title: HEMOFILTRATION CONTROL SYSTEM
Agency: HHS
Contract: N/A
Award Amount: $410,000.00
 

Abstract:

HEMOFILTRATION IS INCREASINGLY USED AS A TREATMENT OF PATIENTS WITH ACUTE RENAL FAILURE AND AN ALTERNATIVE TO DIALYSIS. AN INFUSION DEVICE MUST PROVIDE SUBSTITUTION FLUID AT A CONTROLLED LOWER RATE THAN THAT OF LIQUID REMOVAL FOR NET REDUCTION OF BODY WATER. HEMOFILTER USE IS LIMITED BY DECREASE IN ULTRAFILTRATION RATE CAUSED BY PROTEIN BUILDUP AT THE BLOOD SURFACE OF THE MEMBRANE. APPLICATION OF SUCTION TO THE ULTRAFILTRATION PORT INCREASES ULTRAFILTRATION AND HEMOFILTER LIFE, BUT ELIMINATES OTHERWISE AUTOMATIC DECREASE OF ULTRAFILTRATION WITH ARTERIAL PRESSURE, RISKING AN INTOLERABLE FLUID REMOVAL RATE. TO ALLEVIATE THE DRAWBACKS, THE DEVELOPMENT IS PROPOSED OF AN INTEGRATED MODULAR SYSTEM, CONTAINING ALL PUMPING AND CONTROL DEVICES TO OPTIMIZE HEMOFILTRATION, IN A SMALL AND LIGHT PACKAGE THAT CAN BE MOUNTED ON A BED OR LITTER. THE HEMOFILTRATION CONTROL SYSTEM INCLUDES A HEMOFILTER PUMP, CONTROLLING ULTRAFILTRATION AS A FUNCTION OF TRANSMEMBRANE PRESSURE AND ARTERIAL INLET PRESSURE; A NON-GRAVITY-DEPENDENT INFUSION DEVICE, IN WHICH FLUID REPLACEMENT RATE IS CONTROLLED BY AN ULTRAFILTRATION RATE SIGNAL FROM THE HEMOFILTER PUMP; AND AN IN-LINE BLOOD PUMP FOR USE WHEN ARTERIAL PRESSURE IS TOO LOW TO PROVIDE ADEQUATE BLOOD FLOW.

Principal Investigator:

A. J. Sipin
Principal Investigator
2126955706

Business Contact:

Small Business Information at Submission:

Anatole J. Sipin Co. Inc.
505 Eighth Avenue New York, NY 10018

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No