The study of ocean processes such as mineral dissolution, ion speciation and redox equilibria as well as effluent and pollution monitoring require accurate and precise measurements of both major and minor chemical constituents. although spectrophotometry and flame photometry have been used for sea… More

The use of blood and blood products is extremely important in the treatment of many patients in serious or crisis situations. the value of these materials, and particularly whole blood, has served to emphasize the problems in providing them in all appropriate circumstances. the use ofblood requires… More

The acceptance of extracorporeal oxygenation devices based on gas transfer through a membrane will depend to a large extent on the availability of simpler, easier to use, safer,and lowercost devices. oxygenators using microporous hollowfibers have come into wider use the last five years. they… More

Classical assays for determining blood and urine glucose have limited value for the monitoring of an individual's blood glucose level over time. measurement of glycated hemoglobin (ghb) is already gaining acceptance for management of persons with diabetes mellitus. ghb levels are not only useful for… More

Generally, oxygen affinity increases after treatment of hemoglobin s (hbs) with covalent antisickling agents, such as imidoester crosslinking reagents. adding inositol hexaphosphate (ihp) during the crosslinking procedure will lower the affinity, protect the 2,3-diphosphoglycerate binding site and… More

The understanding of protein function is greatly enhanced bythe availability of three-dimensional structural informationobtained by x-ray crystallography. this is true for membrane as well as water-soluble proteins, but the large, well-ordered three-dimensional crystals required for x-ray analyses… More

It has been estimated that approximately a half-million patients acquire urinary tract infections in acute care hospitals in this country every year. the use of the urinary catheter has been cited as the major cause for such infections, the most numerous of all nosocomial infections. this trend of… More

End-stage renal failure is treated by an extracorporeal dialysis device. over 250,000 patients worldwide are maintained by such thrice weekly treatments. the evolution of the modern dialyzer has been greatly dependent on advances made in polymeric material science. while the modern dialysis unit has… More

PRINCIPAL INVESTIGATOR: Chi, Kefung AWARDEE ORGANIZATION: BioKwitech, Inc. 4204-L Sorrento Valley Boulevard San Diego, CA 92121 TELEPHONE NUMBER: (619) 587-6738 AWARDEE NUMBER: 200-93-0667 Cholera is a very severe epidemic disease caused by cholera toxin (CT) of Vibrio cholerae (V. cholerae). Two… More

PRINCIPAL INVESTIGATOR: Nakano, Eileen T. AWARDEE ORGANIZATION: Hawaii Biotechnology group, Inc. 99-193 Aiea Heights Dr. Aiea, HI 96701 TELEPHONE NUMBER: (808) 486-5333 AWARDEE NUMBER: 200-93-0668 The incidence of measles infections in North America has recently increased. Sequence comparison… More

PRINCIPAL INVESTIGATOR: Slack, John H. AWARDEE ORGANIZATION: Integrated Biotechnology Corp. 11711 North College Ave., Suite 196 Carmel, IN 46032 TELEPHONE NUMBER: (317) 575-7250 AWARDEE NUMBER: 200-93-0669 Measles virus, a severe acute highly contagious human pathogen, is not only responsible for… More

Latex rubber articles in the form of condoms and gloves are used as barriers against the transmission of infectious diseases. The medical community have identified the use of condoms as an effective means for preventing the transmission of the human immunodeficiency virus (HIV) and other sexually… More

PRINCIPAL INVESTIGATOR: Levin, Andrew E. AWARDEE ORGANIZATION: Immunetics 380 Green Street Cambridge, MA 02139 TELEPHONE NUMBER: (617) 492-5416 AWARDEE NUMBER: 200-93-0666 The research program is aimed at providing a simple and reliable serological test which can be used in clinical laboratories,… More

PRINCIPAL INVESTIGATOR: Reynolds, Steven H. AWARDEE ORGANIZATION: Life Sciences, Inc. 2900 72nd Street, North St. Petersburg, FL 33710 TELEPHONE NUMBER: (813) 345-9371 AWARDEE NUMBER: 200-93-0680 Tuberculosis is reemerging as a health threat in the United States. Primary reasons include the… More

PRINCIPAL INVESTIGATOR: Sonesson, Anders AWARDEE ORGANIZATION: Microbial Insights, Inc. 201 Center Park Dr., Suite 1140 Knoxville, TN 37922 TELEPHONE NUMBER: (615) 966-7356 AWARDEE NUMBER: 200-93-0681 In response to the resurgent epidemic of tuberculosis which has been greatly stimulated by the… More

PRINCIPAL INVESTIGATOR: Garcia, Jorge L. AWARDEE ORGANIZATION: Berkeley Antibody Company 4131 Lakeside Drive, Suite B Richmond, CA 94806-1965 TELEPHONE NUMBER: (510) 222-4940 AWARDEE NUMBER: 200-93-0609 A number of wildlife species are natural reservoirs for zoonotic disease pathogens in the U. S.… More

Glutathione S-transferases (GSTs) are a complex multigene family of isozymes considered by many to be the single most important class of enzymes involved in the detoxication of endogenous and xenobiotic electrophilic substances including anticancer drugs. Some of these isozymes are polymorphic and… More

Recently latex allergic hypersensitivity has emerged as a new and unexpected health care problem. Latex rubber is used in many products where tissue contact is possible for both the health care practitioner and the patient. Rates of latex hypersensitivity for hospital physicians and nurses are… More

Often with little knowledge of the per treatment efficiency as related to the individual patients needs, Hemodialysis is prescribed for over 400,000 patients worldwide. A methodology and apparatus are proposed for the quantification of urea removal during treatment. A prototype urea sensor will be… More

The understanding of protein function is greatly enhanced by the availability of three-dimensionalinformation obtained by X-ray crystallography. Unfortunately the large, well-ordered three-dimensionX-ray analyses have been difficult to produce for membrane proteins since they tend more naturally… More

The use of extracorporeal, based therapies continues to grow (dialysis, emo, pherisis, detoxification, etc). in every case the use of extracorporeal circulation requires systemic anticoagulation to prevent thrombosis. heparin has been the standard anticoagulant used and is safe and effective in most… More

The understanding of protein function is greatly enhanced by the availability of three-dimensionalinformation obtained by X-ray crystallography. Unfortunately the large, well-ordered three-dimensionX-ray analyses have been difficult to produce for membrane proteins since they tend more naturally… More

Not Available Reveo, Inc. has invented a proprietary low cost pigment technology having the unprecedented quality that it can be designed to be highly reflective at any wavelength in the range of less than 300 nm to more than 3000 nm with a reflective bandwidth in the range of less than 40 nm to… More

DESCRIPTION: (provided by applicant) Ainphipols are low molecular weight (

DESCRIPTION: (provided by applicant) Ainphipols are low molecular weight (

DESCRIPTION (provided by applicant): Glycosphingolipids and cholesterol form associations with important signaling proteins, within biological membranes forming what are called "rafts". These rafts are characterized by their insolubility even in the presence of many detergents used in membrane… More

DESCRIPTION (provided by applicant): The importance of brain-derived G protein-coupled receptors (GPCRs) in mental function and health can hardly be overstated. However, our knowledge of the molecular biophysical basis for how GPCRs bind to their cognate agonists and antagonists to elicit… More