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THROMBORESISTANT MATERIAL FOR EXTRACORPOREAL DEVICES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
19301
Program Year/Program:
1996 / SBIR
Agency Tracking Number:
19301
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANATRACE, INC.
ANATRACE, INC. 26111 Miles Rd Cleveland, OH 44128 5933
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1996
Title: THROMBORESISTANT MATERIAL FOR EXTRACORPOREAL DEVICES
Agency: HHS
Contract: N/A
Award Amount: $749,427.00
 

Abstract:

THE USE OF EXTRACORPOREAL, BASED THERAPIES CONTINUES TO GROW (DIALYSIS, EMO, PHERISIS, DETOXIFICATION, ETC). IN EVERY CASE THE USE OF EXTRACORPOREAL CIRCULATION REQUIRES SYSTEMIC ANTICOAGULATION TO PREVENT THROMBOSIS. HEPARIN HAS BEEN THE STANDARD ANTICOAGULANT USED AND IS SAFE AND EFFECTIVE IN MOST INSTANCES; HOWEVER, THE USE OF HEPARIN MAY BE ASSOCIATED WITH ADVERSE SIDE EFFECTS SUCH AS THROMBOCYTOPENIC AND HEMORRHAGE. MEMBRANE OXYGENATION IN NEONATES, A SUCCESSFUL AND GROWING TREATMENT, CAN CAUSE INTRACRANIAL HEMORRHAGE BECAUSE OF HEPARIN USE. PAST AND ONGOING WORK BY THE APPLICANT ORGANIZATION ON POLYALKYLSULFONE POLYMERS (BIOBLAND (R)) HAVE BEEN DIRECTED TO COATING HOLLOW FIBERS WITH ONE MEMBER OF THIS FAMILY (BIOBLAND-16 (R)). THIS POLYMER COATING HAS HIGH GAS PERMEABILITY AND EXCELLENT BIOCOMPATIBILITY. WE WILL MODIFY THIS POLYMER VIA COPOLYMERIZATION WITH FUNCTIONALLY ACTIVE MONOMERS, TO FORM MOLECULAR STRUCTURES AMENABLE TO FURTHER DERIVATIZATION TO YIELD PHARMACEUTICALLY ACTIVE NON-THROMBOGENIC SURFACES.

Principal Investigator:

Don N Gray
4198913030

Business Contact:

Small Business Information at Submission:

Anatrace Inc.
1280 Dussel Drive Maumee, OH 43537

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No