NANOELECTRODE ENSEMBLES FOR NEUROCHEMICAL ANALYSIS
DESCRIPTION: Nanoelectrode ensembles for neurochemical analysis are proposed.
The proposed neurochemical probe can provide high performance measurements of
neurochemical species that can help to reduce the burden of human illness and
dysfunction from brain neuro-system causes and to understand each of these
elements and how they interrelate.
Electrochemical voltammetry has shown great promise for direct measurements of
a variety of neurochemical species in neurosystems, however, the existing
single probe microelectrodes have limitations that are not suitable for high
performance voltammetric measurements. This program seeks to develop nano-meter
scale electrode ensembles that are significantly faster, more sensitive, and
reliable than existing microelectrodes. A novel template synthesis approach
will be used to prepare nanoelectrode ensembles, and the innovation will focus
on nano-engineering of the electrode structure that can provide advantages from
the engineered nanostructure. The proposed nanoelectrode ensembles are expected
to have significantly enhanced interfacial diffusivities and reduced
double-layer capacitance enabling high speed measurements with low detection
limits and high selectivity.
During Phase I, AMSEN Technologies will demonstrate the proof-of-concept of
such an electrode ensemble. The proposed innovation can be extremely useful for
neurochemical analysis in applications where sensitive, selective, fast, and
highly localized detection and monitoring of neurotransmitters are needed.
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
Small Business Information at Submission:
Principal Investigator:Ayyasamy Aruchamy
1684 S RESEARCH LOOP, STE 518 TUCSON, AZ 85710
Number of Employees: