MECHANISM-BASED ELASTASE INHIBITORS

Award Information

Agency: Department of Health and Human Services	Branch: N/A	Award ID: 7306	Program Year/Program: 1987 / SBIR
Agency Tracking Number: 7306	Solicitation Year: N/A	Solicitation Topic Code: N/A	Solicitation Number: N/A

Small Business Information: AMT, INC.
508 HEARTWOOD RD CHERRY HILL, NJ 08003 CHERRY HILL, NJ 08003
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Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No

Phase 1: Fiscal Year: 1987

Title: MECHANISM-BASED ELASTASE INHIBITORS

Agency: HHS

Contract: N/A

Award Amount: $50,000.00

Abstract:
SYNTHETIC ELASTASE INHIBITORS FOR USE IN THE TREATMENT OF EMPHYSEMA WILL BE DEVELOPED. IN PHASE I, NEW MECHANISM-BASED ELASTASE INHIBITORS WILL BE SYNTHESIZED, CHARACTERIZED, AND STUDIED AS INHIBITORS OF ELASTASE IN VITRO. THESE INHIBITION STUDIES WILL ANALYZE BOTH THE REVERSIBLE BEHAVIOR OF THE INHIBITORS AND THE TIME-DEPENDENT, IRREVERSIBLE ELASTASE INACTIVATION. AFTER THE CHEMISTRY OF THE ELASTASE INACTIVATION HAS BEEN ELUCIDATED IN PHASE I, A STRUCTURE-ACTIVITY STUDY WILL BE CARRIED OUT IN PHASE II TO DEVELOP THE MOST POTENT ELASTASE INHIBITORS. BECAUSE THE ABSENCE OF NATURAL ELASTASE INHIBITORS IN THE LUNG IS BELIEVED TO BE RESPONSIBLE FOR MUCH OF THE PATHOGENESIS OBSERVED IN EMPHYSEMA, THESE NEW SYNTHETIC ELASTASE INHIBITORS SHOULD BE VERY VALUABLE FOR USE IN REPLACEMENT THERAPY FOR PATIENTS WITH EMPHYSEMA.

Principal Investigator:
Clare biswas phd
3016571700

Business Contact:

Small Business Information at Submission:

Andrulis Research Corp
7315 Wisconsin Avenue Suite 650n Bethesda, MD 20814

EIN/Tax ID:

DUNS: N/A

Number of Employees: N/A

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No