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Anti-apoptotic Mechanism of SF/HGF Mimetics

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65866
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
AA014718
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANGION BIOMEDICA CORPORATION
51 Charles Lindbergh Blvd Uniondale, NY -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Anti-apoptotic Mechanism of SF/HGF Mimetics
Agency: HHS
Contract: 1R43AA014718-01
Award Amount: $191,709.00
 

Abstract:

DESCRIPTION (provided by applicant): Apoptotic cell loss triggered by ischemia-reperfusion plays a prominent role in delayed graft function and acute renal failure following kidney transplant. In experimental models of ischemia-reperfusion, treatment with scatter factor/hepatocyte growth factor reduced renal dysfunction and accelerated renal regeneration, in part by attenuating apoptotic cell death. Using phage display technology and molecular modeling we recently identified C6, a small molecule compound, which exhibits scatter factor/hepatocyte growth factor-like cytoprotective effects. Small pilot studies suggest that the anti-apoptotic effect of C6 is mediated by nitric oxide. By delineating the signaling pathways involved in C6 cytoprotection, the proposed SBIR Phase I application can lead to the development of new C6 analogs that specifically target these pathways, maximizing therapeutic potential while minimizing the risk of any side effects. These studies are expected to provide sufficient supporting data for more in depth Phase II studies with the ultimate goal of bringing this compound or other more potent and easily deliverable compounds into clinical trials for the treatment of renal failure.

Principal Investigator:

Prakash Narayan
5165621124
PNARAYAN@ANGION.COM

Business Contact:


5168696400
Small Business Information at Submission:

ANGION BIOMEDICA CORPORATION
14 BOND STREET SUITE 100 GREAT NECK, NY 11021

EIN/Tax ID: 113430072
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No