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Novel Small Molecule Therapeutic for Spinal Cord Injury

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
80662
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
NS053152
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANGION BIOMEDICA CORPORATION
51 Charles Lindbergh Blvd Uniondale, NY -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2006
Title: Novel Small Molecule Therapeutic for Spinal Cord Injury
Agency: HHS
Contract: 1R43NS053152-01A1
Award Amount: $203,973.00
 

Abstract:

DESCRIPTION (provided by applicant): It is estimated that the annual incidence of spinal cord injury (SCI), not including those who die at the scene of the accident, is approximately 11,000 cases each year. The number of living patients in the United States as of December 2003 who have SCI, has been estimated as being approximately 243,000 persons. After initial injury, about half of those affected will remain completely paralyzed below the level of their spinal lesion. In the other half, the lesion is "incomplete" and some movement and/or sensation is preserved. Hepatocyte growth factor (HGF), also known as Scatter factor (SF), was originally identified and cloned as a potent mitogen for hepatocytes, HGF/SF is produced by mesenchyme and acts upon target cells via its receptor, Met. HGF/SF, has documented scattering, proliferative, and protective effects on neurons in the brain, spinal cord, and peripheral nerves and has significant potential as a novel therapeutic for the treatment of brain and spinal cord injures. Administration of ah HGF/SF-like compound holds promise as a new approach to the clinical management of SCI. However, treatment modalities that employ gene- or protein- based formulations are characteristically expensive and difficult to administer. Therefore, therapeutic approaches that employ small molecule mimetics of natural growth and protective factors may be powerful alternatives to such therapies. The primary focus of research at Angion Biomedica is the development of small molecules that regulate SF/HGF/Met signaling to therapeutic advantage. Using phage display technology we have identified novel peptide ligands functionally identical to HGF/SF for Met receptor interaction. Our lead small molecule HGF/SF mimetic has been termed Refanalin (Rf). Preliminary data indicates that Rf recapitulates the biologic activity of HGF/SF in vitro by activating the HGF/SF receptor, Met resulting in impressive pro-proliferative, scattering and anti-apoptotic effects in Schwann cells. In addition Rf appears to stimulate axonal growth. Furthermore, in a preliminary in vivo study using the spinal cord ischemic injury rabbit model, we show an 80 percent recovery benefit for Rf treatment. Administration of this small molecule mimetic of HGF/SF, represents a highly innovative approach to the treatment of spinal cord injures, with significant clinical potential.

Principal Investigator:

Alexander Yuzhakov
5165621278
AYUZHAKOV@ANGION.COM

Business Contact:

Itzhak Goldberg
5163261200
igoldberg@angion.com
Small Business Information at Submission:

ANGION BIOMEDICA CORPORATION
ANGION BIOMEDICA CORP 1050 Stewart Ave. Garden City, NY 11530

EIN/Tax ID: 113430072
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No