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MONOCLONAL ANTIBODIES AGAINST THE MHC OF INBRED RATS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7375
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7375
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Analex Space Systems, Inc.
5175 South Washington Avenue Titusville, FL 32780
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: MONOCLONAL ANTIBODIES AGAINST THE MHC OF INBRED RATS
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE OBJECTIVES OF THIS PROPOSAL ARE TO: (1) PRODUCE ALLOTYPIC MONOCLONAL ANTIBODIES THAT DISTINGUISH CLASS I ANDCLASS II ANTIGENS CODED BY THE RTI LOCI MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) IN THE LABORATORY RAT, AND (2) CHARACTERIZE THE ANTI-MHC MONOCLONAL ANTIBODIES BY BIOCHEMICAL AND GENETIC METHODS TO DETERMINE THEIR ANTIGENIC SPECIFICITY FOR CLASS I AND CLASS II ANTIGENS OF DIFFERENT MHC HAPLOTYPES USING 11 STRAINS OF INBRED RATS. THE ANTIBODIES WILL BE USED IN COMBINATION WITH OTHER PROCEDURES FOR GENETIC DEFINITION WITHIN THE MHC. PHASE I RESEARCH INCLUDED INDUCTION AND CHARACTERIZATION OF ALLOTYPIC MONOCLONAL ANTIBODIES AGAINST THE 10 KNOWN HAPLOTYPES OF THE RAT MHC. PHASE II WILL INCLUDE PRODUCTION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES AGAINST THE 10 KNOWN HAPLOTYPES OF THE RAT MHC.

Principal Investigator:

Harold a hoffman phd
3012511101

Business Contact:

Small Business Information at Submission:

Animal Genetic Systems Inc
628-g Lofstrand Lane Rockville, MD 20850

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No