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Modified Diphtheria Toxin IL-7 Fusion Toxins

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
80908
Program Year/Program:
2006 / SBIR
Agency Tracking Number:
CA121818
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANJIN GROUP, INC.
10 CHILHOWIE CT. COCKEYSVILLE, MD 21030 2202
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2006
Title: Modified Diphtheria Toxin IL-7 Fusion Toxins
Agency: HHS
Contract: 1R43CA121818-01
Award Amount: $152,141.00
 

Abstract:

DESCRIPTION (provided by applicant): Sweeney et al. (1998) originally reported the construction of DAB389IL-7, a fusion protein based on diphtheria toxin (DT), and proposed that this fusion protein could be employed as a therapeutic agent for hematological malignancies, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, acute myelogenous leukemia and Sezary syndrome. Studies by other groups identify potential targets including glioblastomas, adenocarcinomas of lung origin, aggressive breast cancers and chronic colitis (Cosenza et al., 2002, EI-Rawi et al., 2004 and Oshimi et al., 2004). Since the introduction of DAB389IL-7, little work has been performed with the fusion toxin despite the successful introduction of Ontak (DAB389IL-2) into the clinical setting. The failure of the fusion toxin to be more widely developed is in part due to its propensity to induce vascular leak syndrome (VLS). Anjin Group is improving on the original DAB389 DT toxophore used in the construction of DAB389IL-7. A series of modified DT toxophores with decreased propensity to induce VLS is being developed. Additionally, specific proteinases for in situ processing and activation of the fusion toxin are being introduced into the DT toxophore. Cleavage by specific proteinases selectively overexpressed in tumors will further enhance the selectivity of this class of drugs. The experimental aims of Anjin Group's proposed R21 will determine whether an IL-7 receptor-targeted fusion toxin, constructed with these modified DT toxophores, will be effective against IL-7 receptor positive cells and in particular, cells derived from human malignancies.

Principal Investigator:

Johanna C. Vanderspek
4105611434
ANJIN_GROUP@EARTHLINK.NET

Business Contact:

Willia Harrison
5088316383
ANJIN_GROUP@EARTHLINK.NET
Small Business Information at Submission:

ANJIN GROUP, INC.
10 CHILHOWIE CT. COCKEYSVILLE, MD 21030

EIN/Tax ID: 020669751
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No