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Generation of a Modified DT_IL3 Fusion Toxin

Award Information

Agency:
Department of Health and Human Services 		Branch:
N/A 		Award ID:
88938 		Program Year/Program:
2008 / SBIR
Agency Tracking Number:
CA134162 		Solicitation Year:
N/A 		Solicitation Topic Code:
N/A 		Solicitation Number:
N/A
Small Business Information
ANJIN GROUP, INC.
10 CHILHOWIE CT. COCKEYSVILLE, MD 21030 2202
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: Generation of a Modified DT_IL3 Fusion Toxin
Agency: HHS
Contract: 1R43CA134162-01
Award Amount: $122,830.00
 

Abstract:

DESCRIPTION (provided by applicant): A number of protein fusion toxins, composed of the diphtheria toxin (DT) toxophore and a targeting ligand, have been assembled and tested in Phase I clinical trials for the treatment of leukemias. To date, the only FDA approved protein fusion toxin is ONTAK. ONTAK is a DT, interleukin-2 receptor-targeted fusion toxin used to treat persistent or recurrent, cutaneous T-cell lymphoma. Sales of this drug range between 30 and 40M annually. DT-based protein fusion toxins tar geting the interleukin-3 (IL-3) receptor have produced encouraging early clinical results. The goals of this Phase I proposal are to create a DT-IL3 fusion toxin, using a DT toxophore that has been modified to reduce potential for induction of vascular lea k, that is as potent as the existing DT-IL3 fusion toxin. Vascular leakage in humans is a common side effect of fusion toxin therapy and can inhibit development of this class of therapeutic agent. A reduced side effect profilethe chances of a DT-IL3 toxin becoming available to treat patients with AML. reat AML. PUBLIC HEALTH RELEVANCE: This project seeks to determine if a DT-IL3 fusion toxin with reduce VLS profile can developed. This fusion toxin could provide a wider therapeutic window and ther eby enhance

Principal Investigator:

Business Contact:

Small Business Information at Submission:

ANJIN GROUP, INC.
10 CHILHOWIE CT. COCKEYSVILLE, MD 21030

EIN/Tax ID: 020669751
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No