USA flag logo/image

An Official Website of the United States Government

Synthesis and Chararterization of Therapeutics for the Modulation of Bacterial…

Award Information

Agency:
Department of Defense
Branch:
Defense Advanced Research Projects Agency
Award ID:
35698
Program Year/Program:
1997 / SBIR
Agency Tracking Number:
35698
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANTEX BIOLOGOCIS, INC.
300 Professional Drive Gaithersburg, MD 20879
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1997
Title: Synthesis and Chararterization of Therapeutics for the Modulation of Bacterial Virulence
Agency / Branch: DOD / DARPA
Contract: N/A
Award Amount: $98,400.00
 

Abstract:

Acute infectious diseases pose significant problems which include the potential failure of antimicrobial therapy and the serious sequelae that may result. These treatment failures may occur due to a lack of diagnostic information during early onset of the disease, resulting in the use of the incorrect antibiotic or antimicrobial resistance, and the inadequacy of current therapy for ameliorating sequelae. While it is expected that virulence responses of pathogenic microorganisms to host-specific signals play a role in disease, little information is available to utilize in designing novel intervention therapies. The identification of the environmental cues that regulate bacterial virulence should provide a basis to develop approaches to inhibiting pathogenic processes and result in therapeutics for modulating pathogenesis. This Phase I effort will be directed toward the synthesis and in vitro characterization of compounds to modulate (decrease) the expression of virulence factors by pathogenic bacteria. Antex Biologics through the use of its proprietary Nutriment Signal Transduction Technology (NST) has identified specific host enhancers that increase expression of virulence factors by bacterial pathogens. Using analogue chemistry, compounds (anti-enhancers) will be identified to decrease the expression of bacterial virulence.

Principal Investigator:

John Pace
3015900129

Business Contact:

Small Business Information at Submission:

Antex Biologics, Inc.
300 Professional Drive Gaithersburg, MD 20879

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No