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Development of a Microbead Whole Cell Delivery System for Oral Immunization…

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
52790
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
A002-1573
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANTEX BIOLOGOCIS, INC.
300 Professional Drive Gaithersburg, MD 20879
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Development of a Microbead Whole Cell Delivery System for Oral Immunization against traveler's diarrhea
Agency / Branch: DOD / ARMY
Contract: DAMD17-01-C-0026
Award Amount: $68,112.00
 

Abstract:

Antex biologics is developing inactivated whole cell vaccines for oral delivery to prevent infections by bacteria causing traveler's diarrhea. A new, possibly breakthrough, microbead formulation technology is being developed which should be evaluated forits potential to enhance these inactivated whole cell vaccines. These beads should improve the safety, stability and immunogenicity as well as ease of administration of the whole cell vaccine. In this Phase I SBIR, Campylobacter jejuni, a major cause ofdiarrhea, will be prepared as a dry formulation by spray-coating the inactivated bacterial cells onto a sugar/starch microbead core and then covering the antigen-coated core with a methacrylic acid copolymer. The microbeads will be insoluble at gastricpH, but will be readily soluble at higher (intestinal) pH. This formulation will be tested for its oral immunogenicity and efficacy in a mouse model Antex has developed.This effort should provide a means to better achieve immunoprotection against entericinfections, for which no vaccines are now available. It may also establish an approach for more effective oral vaccines against a broad range of infections. Potential populations for use of such a product include deployed military personnel, internationaltravelers, and global and national public health and child immunization programs.

Principal Investigator:

Richard Walker
Director
3015900129
rwalker@antexbiologics.com

Business Contact:

Larry Ellingsworth
Vice President
3015900129
ellingsworthl@antexbiologics.com
Small Business Information at Submission:

ANTEX BIOLOGOCIS, INC.
300 Professional Drive Gaithersburg, MD 20879

EIN/Tax ID: 521563899
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No