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HER-2/neu T Helper/Memory Vaccine for Breast Cancer

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65460
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
CA096169
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ANTIGEN EXPRESS, INC.
ANTIGEN EXPRESS, INC. 100 BARBER AVE WORCESTER, MA 01606
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: HER-2/neu T Helper/Memory Vaccine for Breast Cancer
Agency: HHS
Contract: 1R43CA096169-01A1
Award Amount: $224,700.00
 

Abstract:

DESCRIPTION (provided by applicant): Antigen Express scientists have demonstrated that the li-Key segment of the li protein, acting at an allosteric site of Class II molecules, facilitates charging by suitable vaccine peptides at the antigenic peptide-binding site. The potency is enhanced (>250) times when the N-terminus of the antigenic peptide is linked to the li-Key peptide (li-key/antigenic epitope hybrid). Such hybrids composed of the Her-2/neu (777-789) epitope are much more potent in stimulating T lymphocytes of patients with metastatic breast carcinoma as measured by IFN-gamma release. In order to develop anti-Her-2/neu immunotherapies, we will: 1) design 9 li-Key/Her-2/neu hybrids using peptides predicted (or previously demonstrated experimentally) to act as good MHC class II epitopes and test their activity in vivo; 2) design and test in vivo a double hybrid composed of the most potent li-Key/Her-2/neu hybrid further linked to an experimentally proven CTL epitope; and 3) characterize the efficacy of our most potent double hybrid in a murine tumor model. We expect a robust augmentation of CTL activity to be obtained through enhanced Th memory/activity by li-Key. These studies address key questions to justify clinical trials with li-Key/HER-2neu antigenic epitope hybrids peptide vaccines in the treatment of breast cancer.

Principal Investigator:

Robert E. Humphreys
5088528801
ANTIGENEXP@AOL.COM

Business Contact:

Robert Humphreys
5088528801
ANTIGENEXP@AOL.COM
Small Business Information at Submission:

ANTIGEN EXPRESS, INC.
ANTIGEN EXPRESS, INC. 100 BARBER AVE WORCESTER, MA 01606

EIN/Tax ID: 043208418
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No