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PROSPECTIVE BROAD-SPECTRUM ANTIBACTERIAL AGENT

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7872
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
7872
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Antivirals Inc
249 Sw Avery Aave Corvallis, OR 97333
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: PROSPECTIVE BROAD-SPECTRUM ANTIBACTERIAL AGENT
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

BASED ON WORK PUBLISHED IN 1981 BY JAYARAMAN, MCPARLAND, MILLER, AND TS'O (PNAS 78 1537 (1981) WE PROPOSE THAT A NOVEL TYPE OF ULTRA-BROAD-SPECTRUM ANTIBACTERIAL AGENT MAY BE POSSIBLE. SUCH AN AGENT WOULD BIND TO A KEY RNA SEQUENCEWHICH IS EXPECTED TO BE HYPERSENSITIVE TO INACTIVATION ONLY IN PROCARYOTES. IF SUCH AN ANTIBACTERIAL AGENT PROVES FEASIBLE THEN THE BASIC APPROACH MAY ALSO ALLOW RATIONAL DESIGN OF BROAD-SPECTRUM AGENTS EFFECTIVE AGAINST OTHER CLASSES OF PATHOGENS - INCLUDING PARTICULARLY FUNGI. HEREIN WE PROPOSE TO PREPARE A VARIETY OF UNCHARGED STEREOREGULAR SEQUENCE-SPECIFIC NUCLEIC BINDING AGENTS TARGETED AGAINST THE SHINE-DALGARANO CONSENUS SEQUENCE OF PROCARYOTIC MRNA'S AND AGAINST ITS COMPLEMENTARY SEQUENCE IN BSCTERIAL 16S RRNA. SPECIAL MODIFICATIONS WILL BE INCORPORATED TO VARY THEIR TARGET BINDING AFFINITIES OVER A BROAD RANGE. THESE SUBSTANCES WILL BE ASSESSED IN BOTH BACTERIA AND ANIMAL CELLS FOR INHIBITION OF PROTEIN SYNTHESIS AND EFFECT ON CELL GROWTH AND DIVISION.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Antivirals Inc
249 Sw Avery Aave Corvallis, OR 97333

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No