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THE U.

Award Information

Agency:
Department of Defense
Branch:
Army
Award ID:
832
Program Year/Program:
1984 / SBIR
Agency Tracking Number:
832
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Anver Bioscience Design, Inc.
160 E MONTECITO AVE Sierra Madre, CA 91024
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1984
Title: THE U.
Agency / Branch: DOD / ARMY
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE U.S. ARMY MEDICAL RESEARCH AND DEVELOPMENT COMMAND HAS THE RESPONSIBILITY FOR DISCOVERING AND DEVELOPING PHARMACEUTICALS THAT WILL PROTECT THE SOLDIER AGAINST NERVE GAS AGENTS THAT ARE A THREAT IN WARFARE. ONE CONCEPT UNDER CONSIDERATION CONSISTS IN ADMINSITRA TION OF A PROTECTIVE DRUG PRIOR TO A NERVE GAS CHALLENGE. THE PRETREATMENT DRUG HAS A PROPHYLACTIC ACTIVITY PROTECTING THE SUBJECT AGAINST THE HARMFUL EFFECTS OF THE GAS. THE CARBAMATE DRUG PYRIDOSTIGMINE IS NOW BEING INVESTIGATED FOR THIS USE. PYRIDOSTIGMINE, A QUATERNARY, PROBABLY ACTS BY TEMPORARILY BLOCKING PERIPHERAL CHOLINESTERASE. IT WOULD BE USEFUL TO HAVE A HIGH ACTIVITY, LOW TOXICITY PROPHYLACTIC DRUG THAT WILL ACT IN THE CENTRAL NERVOUS SYSTEM AS WELL AS PERIPHERALLY, AS AN ALTERNATIVE TO PYRIDOSTIGMINE. THE DRUGS IN THIS PROJECT ARE DESIGNED TO PENETRATE INTO THE CNS WHERE THEY CAN PROVIDE ADDED PROTECTION AGAINST NERVE GAS AGENTS. FOUR NEW CARBAMATE TARGET CANDIDATES WILL BE SYNTHESIZED AND TESTED FOR PROTECTIVE ACTION AGAINST A CHALLENGE TO ACETYLCHOLINESTERASE BY AN ORGANOPHOSPHOROUS SUBSTRATE. HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WILL BE USED TO MONITOR THE PROTECTIVE ACTION OF THE DRUG ON THE ENZYME. AN INHIBITION OF THE HYDROLYSIS OF THE SUBSTRATE BY THE ENZYME WILL INDICATE POTENTIAL IN VIVO PROPHYLACTIC ACTIVITY FOR THE NEW DRUG.

Principal Investigator:

Anthony j. verbiscar
8183551568

Business Contact:

Small Business Information at Submission:

Anver Bioscience Design, Inc.
160 East Montecito Avenue Sierra Madre, CA 91024

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No