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THIS PROJECT COMPRISES AN INVESTIGATION OF POLYSACCHARIDES OF ASTRAGALUS…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4725
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4725
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Anver Bioscience Design, Inc.
160 E MONTECITO AVE Sierra Madre, CA 91024
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THIS PROJECT COMPRISES AN INVESTIGATION OF POLYSACCHARIDES OF ASTRAGALUS VARIETIES THAT WILL INHIBIT CARCINOGENESIS.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THIS PROJECT COMPRISES AN INVESTIGATION OF POLYSACCHARIDES OF ASTRAGALUS VARIETIES THAT WILL INHIBIT CARCINOGENESIS. IN PHASE I, POLYSACCHARIDES FROM FIVE ASTRAGALUS VARIETIES WILL BE PURIFIED, IDENTIFIED, AND SCREENED FOR ANTI- CARCINOGENICITY. FRESH SAMPLES OF THE POLYSACCHARIDES WILL BE IDENTIFIED BY SOLUTION VISCOSITY, ACIDITY, OPTICAL ROTATION, STABILITY, MOLECULAR SIZE, AND INFRARED SPECTRA. THE POLYSACCHARIDES WILL THEN BE TESTED FOR PROTECTIVE ACTIVITY IN TWO DIFFERENT SYSTEMS. THE FIRST SYSTEM COMPRISES NIH-SWISS MICE CHALLENGED WITH A RETROVIRUS ISOLATED FROM WILD MICE THAT LEADS TO A SPLENIC LYMPHOMA. THEY WILL ALSO BE TESTED FOR PROTECTIVE ACTIVITY AGAINST MAMMARY TUMOR DEVELOPMENT IN SPRAGUE-DAWLEY RATS ADMINISTERED THE CHEMICAL CACINOGEN N-METHYL-N-NITROSOUREA. SIMILAR POLYSACCHARIDES HAVE BEEN SHOWN TO PROTECT MICE AGAINST TRANSPLANTED ASCITES TUMORS, PROBABLY BY A BIOLOGICAL RESPONSE MODIFIER MODE OF ACTION. THE PROJECT WILL BEGIN TO SYSTEMATICALLY DEFINE STRUCTURE-ACTIVITY RELATIONS IN ASTRAGALUS POLYSACCHARIDES AS INHIBITORS OF CARCINOGENESIS. THE GOAL IS A PLANT DERIVED, NONTOXIC POLYSACCHARIDE THAT WILL PREVENT THE FORMATION OF TUMORS OR AID IN THE TREATMENT OF CANCER.

Principal Investigator:

Anthony j verbiscar
PRINCIPAL INVESTIGATOR
8183551568

Business Contact:

Small Business Information at Submission:

Anver Bioscience Design Inc
160 East Montecito Avenue Sierra Madre, CA 91024

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No