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Hepatitis C Virus RNA Quantitation Using The 3'NTR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
55758
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
2R44AI046064-02
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
APATH, LLC
APATH, LLC 893 N. WARSON RD. SAINT LOUIS, MO 63141
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: Hepatitis C Virus RNA Quantitation Using The 3'NTR
Agency: HHS
Contract: N/A
Award Amount: $0.00
 

Abstract:

DESCRIPTION (provided by applicant):The goal of this proposal is to establish the value of the 3' noncoding region (NTR) of hepatitis C virus ((HCV genome as an amplification target in a viral load assay. HCV is the most prevalent chronic bloodborne infection in the U.S. Although the number of new infections has declined substantially, there are still an estimated 36,000 new infections each year and approximately 1.8 percent of the U.S. population (3.9 million) is chronically infected. As much as 40 percent of chronic liver disease is HCV related and this results in up to 10,000 deaths each year. The presence of anti-HCV antibody does not distinguish between acute, chronic, or resolved infection nor can anti-HCV antibody levels be used to monitor disease progression or therapeutic efficacy. Quantitative measurement of HCV RNA levels in serum has been successfully used to predict response to therapy. Several qualitative and quantitative HCV RNA assays have been developed, but none is without technical problems and none has yet received FDA approval. Optimal management of HCV infections and further progress toward understanding HCV pathogenesis will depend on ongoing efforts to maximize the performance of HCV RNA load assays. This proposal targets a unique region of the genome which may be critical to achieving this goal. PROPOSED COMMERCIAL APPLICATIONS: Measurement of the level of HCV RNA in serum is becoming an increasingly important component of the management of patients who are chronically infected with HCV. Optimal management of HCV infections will depend on continued efforts to maximize the performance of HCV RNA load assays. If the 3'NTR proves to be the optimal genomic target for measuring HCV RNA, the work proposed here will be directly applied to a commercially and clinically valuable HCV viral load test.

Principal Investigator:

Paul D. Olivo

Business Contact:


3148128160
OLIVO@APATH.COM
Small Business Information at Submission:

APATH, LLC
893 N WARSON RD ST. LOUIS, MO 63141

EIN/Tax ID: 431828778
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No