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Construction of a Respiratory Syncytial Virus Replicon

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65941
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
AI055112
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
APATH, LLC
APATH, LLC 893 N. WARSON RD. SAINT LOUIS, MO 63141
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Construction of a Respiratory Syncytial Virus Replicon
Agency: HHS
Contract: 1R43AI055112-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): Respiratory syncytial virus (RSV) is the most important respiratory pathogen in infants, especially those born prematurely. It is also an important cause of disease in the elderly and immunosuppressed. There is no vaccine available to protect against RSV and "at risk" infants are presently treated by passive immunization. An effective small molecule drug that prevents RSV infection or ameliorates it would be of great value. The goal of this Phase I proposal is to develop a novel "replicon" system for screening potential antiviral compounds. The RSV replicon will be a genetically modified viral genome missing its three glycoprotein genes. The replicon will contain a drug-resistance gene to select cells that contain the replicon and a marker gene to easily assay virus replication and gene expression. This system will provide a useful molecular tool for rapid screening of compounds that inhibit any pathway involved in RSV genome replication, mRNA transcription, or translation. An RSV replicon will also be valuable for genetic studies of RSV and in efforts to use RSV as a vector.

Principal Investigator:

Paul D. Olivo
3148128144
OLIVO@APATH.COM

Business Contact:

Janet Milton
3148128160
MILTON@APATH.COM
Small Business Information at Submission:

APATH, LLC
893 N. WARSON RD. ST. LOUIS, MO 63141

EIN/Tax ID: 431828778
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No