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Diagnostic for Age-Related Macular Degeneration

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
75832
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
AG026222
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
APELIOTUS TECHNOLOGIES, INC.
1456 N MORNINGSIDE DR NE ATLANTA, GA 30306 3240
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Diagnostic for Age-Related Macular Degeneration
Agency: HHS
Contract: 1R43AG026222-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): Apeliotus Technologies proposes to develop a commercial diagnostic for the early detection of age-related macular degeneration (ARMD). It relies on a functional test of dark adaptation kinetics (the transition from being light-adapted to being dark-adapted) that has been shown in previous work to detect the onset of ARMD at least four years before it is clinically evident. Testing is completely non-invasive and can be performed by an unskilled operator with a minimum of patient burden. ARMD is the leading cause of untreatable blindness for older adults in developed countries, affecting an estimated 30 million people worldwide and 13 million people in the US. The problem is expected to get significantly worse as the population ages. One challenge in addressing this health threat is the development of methods to discriminate normal aging from early (sub-clinical) disease onset. The proposed ARMD diagnostic has tremendous potential as a doctor's office screening tool for identification of at-risk and treatment populations. Equally important, it can provide a sensitive outcome measure for evaluating the early-stage impact of the many drugs and nutritional supplements being developed for ARMD. Developing these capabilities could result in substantially improved quality of life for older adults. The overall goal of this program is to demonstrate =90% sensitivity and =90% specificity for early-stage ARMD using the proposed diagnostic with a simple, rapid test protocol. The specific aim of this Phase I proposal is to demonstrate the feasibility of discriminating early-stage ARMD patients from normal old adults in = 20 minutes. A preliminary commercial prototype will be built with device parameters and a test protocol optimized for rapid determination of dark adaptation impairment, and a 40-person clinical study (20 early-stage ARMD patients; 20 normal old adults) will be conducted to confirm that discrimination is possible within the targeted time.

Principal Investigator:

John G. Edwards
9145944166
JGEDWARDS@NYMC.EDU

Business Contact:


4048759561
Small Business Information at Submission:

Apeliotus Technologies, Inc.
Apeliotus Technologies, Inc. 1456 N Morningside Dr Ne Atlanta, GA 30306

EIN/Tax ID: 200730798
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No