Automatic Metaphase Spread Finder using Novel ScanScope
DESCRIPTION (provided by applicant): Manual slide scanning is one of the most
tedious and time-consuming elements of cytogenetic analysis. The development
and application of a new automated digital scanning technology, termed
ScanScope, is proposed for efficiently finding all metaphase spreads in a
cytogenetic microscope slide preparation. The ScanScope approach is based on
rapidly scanning and digitizing an entire microscope slide - up to 30 times
faster than conventional approaches - followed by the creation of a large
contiguous digital image that is the basis for finding metaphase spreads.
Preliminary results demonstrate the potential of this novel method to yield
images that are suitable for automatically finding metaphase spreads . We
propose to further study and optimize the rapid scanning of cytogenetic
microscope samples and the development of image processing algorithms, so as to
ultimately provide a cost-effective method for finding metaphase spreads that
is rapid and fully automatic, yet reliable enough to be suitable for routine
clinical use. The development of software algorithms is proposed to demonstrate
the feasibility of this improved method for automatically and reliably finding
metaphase spreads in a variety of cytogenetic preparations.
PROPOSED COMMERCIAL APPLICATIONS:
The proposed automatic metaphase spread finder will eliminate manual slide scanning, one of the most tedious and time-consuming elements of cytogenetic analysis. The novel features of the ScanScope are expected to enable the cost-effective development of a rapid, fully automatic and reliable instrument that is suitable for routine clinical use at some 1000 potential sites. Rapid adoption by clinical laboratory is expected because productivity increases resulting from use of a ScanScope metaphase spread finder translate into payback periods less than 12 months.
Small Business Information at Submission:
Principal Investigator:Dirk G. Soenksen
APERIO TECHNOLOGIES, INC.
3386 AVENIDA NIEVE, STE G CARLSBAD, CA 92009
Number of Employees: