The overall goal of this R&D program is to develop improved methodologies and manufacturingprocesses for the isolation of marine natural products with anticancer or anti-HIV activity. Thetherapeutic potential of marine natural products has rapidly advanced in recent years. One suchpotential… More

This investigation is aimed at devising ways and special instrumentation for using fluorescentlanthanide chelates, detected by time resolved fluorometry, as a means for detecting nucleic acids in avariety of settings such as Southern blots and cells or tissues (e.g., as in situ hybridization).… More

Numerous compounds showing antineoplastic activity have been identified in the organic solvent extracts of plant material, microorganisms, and marine organisms. further investigation into the utility of these compounds as chemotherapeutic and anti-hiv agents has been hampered by their low natural… More

Michellamine B is a potential anti-HIV agent isolated from the leaves of a Cameroonian vine,Ancistrocladus korupensis, which grows in the Korup region of Cameroon. Preclinical testing ofMichellamine B by the National Cancer Institute may be adversely impacted by raw materials availability,and the… More

Many pyrotechnics contain valuable resources which could be used in commercial applications, for example metals (e.g. magnesium, aluminum); metallic salts of copper, strontium, and barium; oxidizer (e.g. sodium nitrate, potassium Perchlorate); binders such as viton, and dyes which have reclaimed… More

Not Available Technical Abstract (Limit your abstract to 200 words with no classified or proprietary information/data.) MSSI proposes the use of ultra wideband (UWB), nanosecond duration pulses for a fusing sensor waveform to determine the ordinance to target range with an accuracy of better than… More

DESCRIPTION (provided by applicant): Marijuana (Cannabis sativa) and a number of cannabinoids including its primary psychoactive component, delta9-THC (delta9-tetrahydrocannabinol), show promise for treating pain and cachexia in cancer and AIDS patients. The overall goal of this research program is… More

DESCRIPTION (provided by investigator): The terrorist events of September 11th and the recent criminal anthrax exposures have increased awareness of the use of smallpox as a biological weapon. A shortage of the vaccine and the incidence of vaccine-related deaths will preclude protection of everyone… More

DESCRIPTION (provided by applicant): Influenza is a common and serious respiratory illness affecting tens of thousands each year and causing 20,000 - 40,000 deaths. This significantly contributes to the loss of manpower hours and revenue each year. Annual vaccine programs are in place to protect… More

DESCRIPTION (provided by applicant): Currently, there are 42 million AIDS cases worldwide, with a majority present in the third world; 3.1 million deaths can be attributed to HIV and AIDS in 2002 alone. There is no vaccine against HIV, and AIDS, if untreated, will lead to the death of over 95% of… More

DESCRIPTION (provided by applicant): Prostate cancer is the most prevalent cancer among men; and the second leading cause of cancer death among men in the US. There are currently no approved therapies for hormone-refractory prostate cancer. Epidemiological studies have demonstrated a strong… More

DESCRIPTION (provided by applicant): ?9-tetrahydrocannabinol (?9-THC) has been shown to alleviate marijuana withdrawal symptoms and thus has potential for treating cannabinoid dependence. However, the bioavailability of ?9-THC administered orally is poor a nd variable. In addition, it also requires… More

The aim of this project is the development of Tyrosyl DNA phosphodiesterase (Tdp1) inhibitors in order to enhance the activity of DNA topoisomerase I inhibitors.

DESCRIPTION (provided by applicant): The worldwide AIDS epidemic, the periodic emergence of Ebola and SARS, and the recent outbreaks of potentially pandemic strains of influenza such as H5N1 have highlighted a persistent concern in the health- care communi ty -- the need for effective sterilization… More

DESCRIPTION (provided by applicant): Alzheimer's Disease (AD) is a significant neurological disorder that afflicts more than 4.5 million Americans and more than 10 million people worldwide. The lack of a cure for AD will result in a demand for better and s afer AD drugs. All of the drugs on the… More

DESCRIPTION (provided by applicant): Alzheimer's Disease (AD) is a significant neurological disorder that afflicts more than 4.5 million Americans and more than 10 million people worldwide. The lack of a cure for AD will result in a demand for better and safer AD drugs. All of the drugs on the… More

This Phase I, SBIR contract is to conduct a thorough biological and phytochemical analysis of Harpagophytum procumbens. This should result in discovery of new biologically active molecules and/or a more comprehensive understanding of the contributions madeby the known constituents.

The contractor will identify methodologies for broad spectrum inactivation of pathogens in red blood cell concentrates(RBCC). RBCCs are the main components of blood used in transfusion medicine, yet currently there are no FDAapproved methods for broad spectrum pathogen inactivation for RBCCs;… More