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Company Information:

Name: APPLIED GENETICS LABORATORIES
Address: 1335 GATEWAY DR, STE 2001
MELBOURNE, FL 32904
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
URL: N/A
Phone: (407) 768-2048

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,121,879.00 13
SBIR Phase II $5,284,903.00 9

Award List:

MOLECULAR ANALYSIS OF TK AND HPRT GENE MUTATIONS IN L5178Y MOUSE LYMPHOMA CELLS

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: John Hozier Phd
Award Amount: $49,000.00

MOLECULAR ANALYSIS OF TK AND HPRT GENE MUTATIONS IN L5178Y MOUSE LYMPHOMA CELLS

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator: John Hozier Phd
Award Amount: $374,874.00
Abstract:
Applied genetics laboratories, inc. proposes to utilize newly developed molecular genetic techniques to analyze the spectrum of mutagenic events that occur at the tk and hprt loci in mouse l5178y cells. the purpose of these studies isto determine if the spectrum of genetic abnormalities registered… More

SEQUENCE ANALYSIS OF TK AND HPRT GENE MUTATIONS

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Melissa Liechty
Award Amount: $49,881.00

SEQUENCE ANALYSIS OF TK AND HPRT GENE MUTATIONS

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: Melissa Liechty
Award Amount: $399,253.00
Abstract:
Recently developed molecular techniques will be used to analyze mutations at the tk locus in mouse l5178y cells exposed to chemical mutagens. because mutation assays measure phenotype, not genotype, scored mutations could result from other mechanisms. sequence analysis will determine whether the… More

Mouse Chromosome-Specific Painting Probes

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Melissa C. Liechty
Award Amount: $49,945.00

Mouse Chromosome-Specific Painting Probes

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency: HHS
Principal Investigator: Melissa C. Liechty
Award Amount: $735,111.00
Abstract:
We have described a new technology called "preparative in situ hybridization (Prep-I.S.H.), which is capable of isolating a set of cDNA or genomic clones according to their chromosome location. The technology takes advantage of in situ hybridization of cloned DNAs to metaphase chromosome spreads,… More

Polymorphic Markers for Chromosome Band 11e2

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Lisa Davis
Award Amount: $99,980.00
Abstract:
Our research decribes a strategy for producing a high density set of PCR-base microsatellite markerpolymorphic in L5178Y, the cell line used in the mouse lymphoma assay (MLA). These polymorphic marketwo detailed long range restriction maps in the vicinity of the thymidine kinase (tk-1) gene, with… More

Geneid--A New Gene Mapping and Finding System

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Lisa Davis
Award Amount: $99,999.00
Abstract:
This proposal describes a set of reagents which will make gene mapping to chromosomes and chromosomas well as gene finding exercises, accessible to any molecular biologist or geneticist familiar withtechniques. These reagents, called the Gene. ID system, are a set of "dot-blots". The… More

Provide Sequence Analysis of TK and HPRT Gene Mutations

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency: HHS
Principal Investigator: John Hozier
Award Amount: $99,849.00
Abstract:
We propose using new molecular techniques to survey the spectrum of mutagenic events occurring at tL5178Y cells. We will compare this spectrum with the range of abnormalities occurring in human cancemouse lymphoma assy (MLA) as an accurate reflection of events of human significance. … More

Preparation of Mouse Chromosome Painting Kits

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Melissa Liechty
Award Amount: $100,000.00

Microgenetics: Techniques for Screening Large Insert Libraries

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: DOE
Principal Investigator: Saika Aytay
Award Amount: $75,000.00

Shac--Isolation of Chromosome Region Specific CDNA

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Linda Chen-Liu
Award Amount: $99,951.00

ES FOR LAB. SPECIES.

Award Year / Program / Phase: 1996 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $99,671.00

Preparation of Mouse Chromosome Painting Kits

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator: Melissa Liechty
Award Amount: $676,404.00
Abstract:
Fluorescent chromosome painting probes allow identification of a variety of chromosome abnormalitieinterphase and mitotic cells. Mouse cytogenetics, handicapped by difficult chromosome identificationchromosome paints in many research and commercial applications, including in vivo and in vitro… More

Shac--Isolation of Chromosome Region Specific CDNA

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator: Linda Chen-Liu
Award Amount: $749,794.00
Abstract:
This proposal describes a method for preparing cDNA sublibraries specific to certain chromosome regprocedure, which we call selection of hybrids by affinity capture (SHAC), can be described in two stbanded mitotic chromosomes are microdissected and PCR- amplified using a universal degenerate… More

High Density Genetic and Physical Mapping Reagents

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $750,000.00

N/A

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $749,868.00

CDNA LIBRARY CONSTRUCTION IN SMALL REPRODUCTIVE TISSUES

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Joseph, david r
Award Amount: $98,991.00

MICOTECHNIQUES FOR GENETIC CHANGES IN CARCINOGENESIS

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Hozier, john
Award Amount: $99,745.00

Chromosome Specific DNA Proges for Laboratory Species

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $749,750.00

POSITIONAL CLONING OF GROWTH SUPPRESSORS--A NEW APPROACH

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: HHS
Principal Investigator: Rotenberg, Mitch O
Award Amount: $99,831.00

DEVELOPMENT OF CANCER REGION SPECIFIC MICROARRAYS

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: John C. Hozier
Award Amount: $99,885.00
Abstract:
APPLICANT?S DESCRIPTION: This proposal describes technical approaches for efficient and high throughput production of region specific genomic and cDNA microarrays with the ultimate goal of deciphering cancer-associated genes involved in various human neoplasias. The techniques will be applied to… More