A group of human tumor cell strains has been identified that is more sensitive to growth inhibition produced by human interferon than are other tumor cell strains or normal human fibroblasts. this group of tumor strains, designated the mer-phenotype, shares a biochemical defect in dna repair. these… More

The travel times of coherent events in seismic surveys of the crust principally give information about the low spatialfrequency velocity field; details of the seismic signatures of backscattered events principally give information about the high spatial frequency of the velocity and density fields… More

Skin cancer, resulting from ultraviolet (uv) light damage to dna, has increased dramatically in the united states and throughout the world. applied genetics, inc., has developed a method to enhance dna repair in human cells by treatment with liposomes containing uv-dna repair enzymes. phase i… More

Nitrosoureas are effective antitumor agents, especially in brain cancer. however, tumors are often resistant due to activity of the human dna repair enzyme, o(6)-methylguanine-dna methyltransferase (o6mt). the outcome of chemotherapy may be predicted by measuring the levels of o6mt in single cells… More