UV-DNA REPAIR AND MUTAGENESIS IN LIPOSOME-TREATED CELLS

Award Information

Agency: Department of Health and Human Services	Branch: N/A	Award ID: 13698	Program Year/Program: 1991 / SBIR
Agency Tracking Number: 13698	Solicitation Year: N/A	Solicitation Topic Code: N/A	Solicitation Number: N/A

Small Business Information: Applied Genetics, Inc.
205 Buffalo Ave Freeport, NY 11520
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Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No

Phase 2: Fiscal Year: 1991

Title: UV-DNA REPAIR AND MUTAGENESIS IN LIPOSOME-TREATED CELLS

Agency: HHS

Contract: N/A

Award Amount: $500,000.00

Abstract:
SKIN CANCER, RESULTING FROM ULTRAVIOLET (UV) LIGHT DAMAGE TO DNA, HAS INCREASED DRAMATICALLY IN THE UNITED STATES AND THROUGHOUT THE WORLD. APPLIED GENETICS, INC., HAS DEVELOPED A METHOD TO ENHANCE DNA REPAIR IN HUMAN CELLS BY TREATMENT WITH LIPOSOMES CONTAINING UV-DNA REPAIR ENZYMES. PHASE I RESEARCH WILL MEASURE MUTATION FREQUENCY IN HUMAN CELLS TREATED WITH LIPOSOMES TO DETERMINE IF ENHANCED DNA REPAIR WILL PREVENT MUTATIONS THAT LEAD TO CANCER. THE PATCH SIZE OF REPAIRED REGIONS WILL ALSO BE MEASURED, AND THE REPAIR OF 6-4 PHOTOPRODUCTS IN DNA WILL BE MEASURED. THIS CHARACTERIZATION OF ENHANCED DNA REPAIR WILL ANSWER SOME BASIC SCIENCE QUESTIONS AND IS IMPORTANT BEFORE BEGINNING ANIMAL TESTING OF LIPOSOMES IN PHASE II. THE GOAL IS A TOPICAL LOTION CONTAINING DNA REPAIR LIPOSOMES TO PREVENT SKIN CANCER AFTER UV EXPOSURE.

Principal Investigator:
Daniel Yarosh
5168689026

Business Contact:

Small Business Information at Submission:

Applied Genetics Inc.
205 Buffalo Ave Freeport, NY 11520

EIN/Tax ID:

DUNS: N/A

Number of Employees: N/A

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No