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Natural Adjuvants to enhance Efficacy of Viral Vaccines for Mariculture

Award Information

Agency:
Department of Commerce
Branch:
N/A
Award ID:
99550
Program Year/Program:
2010 / SBIR
Agency Tracking Number:
10-96
Solicitation Year:
N/A
Solicitation Topic Code:
8.1.2F
Solicitation Number:
N/A
Small Business Information
ProFishent, Inc.
17806 NE 26TH ST Redmond, WA 98052-5848
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2010
Title: Natural Adjuvants to enhance Efficacy of Viral Vaccines for Mariculture
Agency: DOC
Contract: WC133R10CN0227
Award Amount: $92,716.00
 

Abstract:

Viral diseases are a major impediment to the development and expansion of environmentally safe and sustainable aquaculture systems (NMFS 2007). Despite control measures, pathogenic viruses kill millions of fish and shellfish every year (ICES Mariculture Committee 2004). To date, vaccines against fish viruses have generally provided extremely poor protection or are too expensive (e.g. DNA vaccines). We will test the feasibility of binding natural marine and terrestrial biological structures to viruses to boost the immunogenicity of viral antigens delivered to the gills and mucosal surfaces of aquatic animals. A nanotechnology-based dynamic light scattering laser instrument will verify the attachment of the model virus particles. Groups of Atlantic Salmon (Salmo salar) will then undergo needle-less, immersion immunization with the most promising vaccine formulations to assess safety and efficacy. Antibody titers will be compared to identify candidate vaccine adjuvant systems for further investigations planned in Phase II research.

Principal Investigator:

David B. Powell
Vice President, R & D
4258839896
davidp@profishent.com

Business Contact:

Roger C. Palm
President
4258839896
rogerp@profishent.com
Small Business Information at Submission:

ProFishent, Inc.
17806 NE 26TH ST REDMOND, WA 98052

EIN/Tax ID: 912025622
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No