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Purification and Culture of Dendritic Langerhans Cells

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
21921
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
21921
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Applied Immune Sciences, Inc.
5301 Patrick Henry Drive Santa Clara, CA 95054
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Purification and Culture of Dendritic Langerhans Cells
Agency: HHS
Contract: N/A
Award Amount: $35,438.00
 

Abstract:

Methods for obtaining highly purified Langerhans Cells (LC) directly from epidermis or by directed differentiation of CD34+ progenitor cells are proposed. Development and commercialization of products for LC purification will aid basic research on the role of LC in skin diseases such as psoriasis, Kaposi's sarcoma and atopic dermatitis. The therapeutic goal of the work is to develop a method of growing LC from bone marrow and use the LC as an antigen presenting cell line for cytotoxic CD8+ T cells. We propose applying this system in an immunotherapeutic approach to AIDS; this system will be based on the use of HIV-associated antigens in the LC culture system. The system may provide a generally applicable method for generation of antigen specific cytotoxic T cells.

Principal Investigator:

David A. Okrongly
4084929200

Business Contact:

Small Business Information at Submission:

Applied Immune Sciences, Inc.
5301 Patrick Henry Drive Santa Clara, CA 95054

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No