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STRUCTURE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4708
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4708
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Applied Medical Technology Inc
6554 Beechwood Dr Independence, OH 44131
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: STRUCTURE
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE LONG-TERM GOAL OF THIS PROJECT IS TO DEVELOP AN IMPLANTABLE ENZYMATIC-ELECTRO-CHEMICAL SENSOR UTILIZING GLUCOSE OXIDASE HOUSED IN A MICRO-TEXTURED CELL WITH ION TEXTURED SURFACES. THESE ION SURFACES ALLOW ALTERATIONS IN THE FIBROUS CAPSULE FORMATION; THE ALTERATIONS PERMIT INTIMATE CONTACT WITH THE TISSUE VASCULATURE TO THE EXCLUSION OF THE FIBROUS CAPSULE. THE SENSING ELEMENT IS CONSTRUCTED WITH AN EXCLUSION MEMBRANE SYSTEM, BIBULOUS FILMWITH ENZYME SOLUTION AND PLATINUM CATALYTIC SURFACE, THUS COMBINING UNIQUE SURFACE MICROSTRUCTURING WITH A RECHARGEABLE ENZYME SYSTEM. DURING PHASE I A PROTOTYPE MODULE WILL BE TESTED FOR FEASIBILITY OF FABRICATING A SENSOR MODULE WITH HOLLOW, METAL-COATED MICROPILLAR STRUCTURES. PHASE II WILL ALLOW FOR CHARACTERIZATION AND REFINEMENT OF THE ENZYME SYSTEM WITH SMALL ANIMAL STUDIES. ISSUES SUCH AS ENZYME STABILITY, MEMBRANE EXCLUSION PROPERTIES, BONDING, BIOCOMPATIBILITY, RESPONSE TIME, AND LINEARITY WILL BE CHARACTERIZED IN IN VITRO AND IN VIVO MODELS. THIS SENSOR WILL PROVIDE MORE THAN 2 MILLION INSULIN DEPENDENT DIABETICS WITH THE FINE DYNAMIC CONTROL REQUIRED WHEN USING AN ARTIFICIAL BETA CELL. IN ADDITION, BASIC TISSUE INTERACTION WITH ITS IMPLANTATION AND CONTROL OF THE SOFT TISSUE BIOLOGIC INTERFACE CAN BE DIRECTLY APPLIED TO A BROAD RANGE OF IMPLANTS AND THEIR DESIGN.

Principal Investigator:

Dennis siedlak
PRINCIPAL INVESTIGATOR
2165895891

Business Contact:

Small Business Information at Submission:

Applied Medical Technology Inc
6554 Beechwood Drive Independence, OH 44131

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No