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Commercialization of a Graphical Pharmacokinetic-Pharmacodynamic Display

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
76262
Program Year/Program:
2007 / SBIR
Agency Tracking Number:
GM066615
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
APPLIED MEDICAL VISUALIZATIONS, LLC
APPLIED MEDICAL VISUALIZATIONS, LLC 231 East 400 South #216 SALT LAKE CITY, UT 84111
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2007
Title: Commercialization of a Graphical Pharmacokinetic-Pharmacodynamic Display
Agency: HHS
Contract: 2R44GM066615-02
Award Amount: $712,046.00
 

Abstract:

DESCRIPTION (provided by applicant): Applied Medical Visualizations L.L.C. has developed a pharmacokinetic-pharmacodynamic display (PkPd Display) intended for anesthesia care providers. In Phase I, we designed a display that was based on a two drug interac tion model, which was previously developed for an opioid (remifentanil) and a sedative hypnotic (propofol) in human volunteers. The measures for this PkPd interaction model include the probability of loss of consciousness and loss of response to various no xious stimuli. The model was evaluated in the operating room on its ability to predict loss and regain of consciousness and to predict non-responsiveness to noxious stimuli in a wide variety of patients. The results were positive. The models adequately pre dicted clinical endpoints of interest to an anesthetist and is hence, commercially viable. For Phase II, several aspects of the PkPd Display merit development and further evaluation prior to commercialization: 1. we will evaluate the usability of the PkPd Display and ensure it will not interfere with other critical aspects of anesthetic delivery and appropriate patient care. The display will be evaluated in both patient simulator and operating room settings. 2. We will expand the number of interaction model s used within the PkPd Display to include other commonly used anesthetics, such as inhaled agents and additional opioids. 3. We will characterize differences in the drug-drug interaction in patients scheduled for elective surgery who chronically consume op ioids, and update the PkPd Display with these results 4. We will implement optimization techniques so that the display's models predict drug combinations that will result in a rapid wakeup by the patient while maintaining adequate analgesia during recovery . If successfully implemented, use of the PkPd Display could result in fewer hypertensive and hypotensive episodes, fewer adjuvant drug interventions, a lower incidence of patient movement, a lower incidence of the need for pharmacologic reversal of opioid effect to restore spontaneous ventilation, and more rapid wakeup at the end of surgery. By generalizing the PkPd models for use with inhaled agents and opioids, the display will be usable in a significantly larger portion of administered anesthetics world wide. By accounting for additional model covariates, such as the opioid tolerant patient, the display can provide accurate predictions for outliers beyond the normal population, possibly reducing risk of respiratory depression and inadequate analgesia. Opt imizing the display will bring intelligence into the display, providing complex optimizations with a simple presentation to the user. 7. PROJECT NARRATIVE Applied Medical Visualizations L.L.C. has developed a graphical drug display intended for anesthesia care providers. This display is intended to help anesthesiologists visualize a patient's level of sedation and analgesia during surgery, resulting in more effective anesthetics and less episodes of inadequate analgesia experienced by the patient.

Principal Investigator:

Noah Syroid
8016719674
NSYROID@MEDVIS.COM

Business Contact:

Agutter
jagutter@medvis.com
Small Business Information at Submission:

APPLIED MEDICAL VISUALIZATIONS, LLC
APPLIED MEDICAL VISUALIZATIONS, LLC 231 East 400 South #216 SALT LAKE CITY, UT 84111

EIN/Tax ID: 710892665
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No